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Weird neurological symptoms

Discussion in 'Neurological/Neuro-sensory' started by optimist, Apr 8, 2015.

  1. optimist

    optimist Senior Member

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    Hello all, and long time since last.

    Sorry for being a bit lengthy here!

    I have the last months been working with a doctor doing functional medicine, and he has been testing me for all sorts of things. He found several issues which he believes can explain my fatigue and many of the other symptoms I am struggling with.
    • Low gut flora diversity
    • Low butyric acid
    • Low IgA in the gut
    • Low cortisol
    • High mercury (22 nmol)
    • Very high gut permiabillity (lactulose/mannitol test was in the upper end of red)
    • Protozo parasites
    • Overmethylated
    He believes that the mercury is the main big issue.

    Now with that background, I was hoping some of you could shed some light on this:

    Just as I was about to get started with treatment I developed some new issues that neither this doctor, nor two other doctors that I've seen can explain. All the nerves in my whole body, mostly arms and legs, would be incredibly overstimulated (for lack of better term/description), lasting for hours at a time. It was tormenting me, and it seemed that it was triggered by eating food. So I reduced eating a lot and lost some kilos. Being 193cm and about 75kg that is not the best.

    The whole thing actually started with muscle twitches and cramps some weeks prior to the outbreak, and after the outbreak the twitches has come and gone, and they appear all over the body, but still mostly in the legs and arms.

    The overstimulation of the nerves has more or less stopped, thank God, but as they have subsided more and more over the last weeks, the muscles in the legs and arms are increasingly feeling weak. Apparently they just feel weak, but are not... or the strength is there, but perhaps not the endurance...

    Last week at the doctor's, I had very little, or close to no, reflex in the knees when being hit with a hammer, but today it was pretty OK. But, today when he asked me to wiggle my wrists back and forth quickly the left hand was keeping a slower tempo than the right one.

    As I have been believing that there is a connection with eating and this my functional doctor thinks there must be a connection with leaky gut and leaky blood brain barrier. And what apparently stopped the overstimulation of the nerves was me starting on a gut healing protocol including:

    • L-Glutamine
    • Glycine
    • Butyric Acid
    • Saccharomyces Boulardii(stimulates IgA production in the gut)
    • Lactobacillus Plantarum
    • Probiotica
    • Zink
    • Selenium
    • Broth since monday
    • and from today, Betaine HCL
    But the weakness is so far progressing, and I do not like it!!!!!
    I am going to see a neurologist and also scheduled for MRI, but as the doctors so far are having no clue what this is - would any of you perhaps?
     
    Last edited: Apr 10, 2015
    merylg, Inspired, oceiv and 2 others like this.
  2. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
  3. optimist

    optimist Senior Member

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    Thank you @ahmo! That's a good suggestion, and a good video. I think saw it around christmas times actually :) But my B12 should be above 500, so that should not be the issue with me...
     
  4. Gondwanaland

    Gondwanaland Senior Member

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    There is a huge gap between lab results and symptoms.
     
    ahmo likes this.
  5. optimist

    optimist Senior Member

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    So.... how then do you propose one can find out if one is deficient? Is there some other way?
    Last time I took one 5000mg B12 tablet I was unable to sleep until the following day (overmethylation) :/
     
  6. Gondwanaland

    Gondwanaland Senior Member

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    Homocysteine and Methylmalonic Acid are the tests to tell you if you have a functional B12 deficiency if the lab handles the blood sample well (I think it must be immediately frozen until analysis?).

    This is a HUGE dose. Have you read caledonia's documents about starting low and roadblocks to methylation? They are linked in my signature under "Freddd's protocol".

    Last year I started with 500mcg and went up too quickly to 1,500 mcg and that was too much for me. Then I found caledonia's documents... Right now I am tolerating 200mcg 1 or 2x weekely.

    EDIT: Also take a look at this:
    http://forums.phoenixrising.me/inde...h-my-23andme-results.36736/page-2#post-583654
     
    Last edited: Apr 9, 2015
  7. optimist

    optimist Senior Member

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    It was quite a while ago that I did it, but I am not doing it again :)

    Here's an excerpt from my blood test, but I am not able to interpret it:
     

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  8. Gondwanaland

    Gondwanaland Senior Member

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    Hey that is a very high serum folate :confused:

    Do you have your SNPs posted somewhere?
     
    Crux likes this.
  9. optimist

    optimist Senior Member

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    No, I have not taken 23andme... but I have tested for mthfr mutation, and it said I have no mutation.
     
  10. optimist

    optimist Senior Member

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    But, as far as B12 goes, does it look OK in regards to homocysteine and methylmalonic acid?
     
  11. Crux

    Crux Senior Member

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    The folate does look too high, and could be involved with the neurological symptoms.
    High folate may be caused by bacterial overgrowth in the gut. SIBO.
     
    Gondwanaland likes this.
  12. Gondwanaland

    Gondwanaland Senior Member

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    Lab results seem fine, but you need to address your symptoms not the results.

    For instance my lab results for thyroid look fine, but I have hypothyroid symptoms and need T3 replacement.
     
  13. optimist

    optimist Senior Member

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    I see... hmm... I have been trying 500mgx3 niacin for some days, but they mostly put my mood down so I stopped taking them, but I know they eat methyl groups. I also tried supplementing with B-Right, but B-complexes gives me anxiety, depression and even more fatigue. Perhaps B-Right being high in folate is playing a part in that...
     
  14. Gondwanaland

    Gondwanaland Senior Member

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    One possibility is that you are not getting the folate into the cells, so taking B3 is worsening your symptoms.

    B-Right contains 125mg B3 and also contains folic acid. So this Bcomplex is probably worsening your condition.

    Hopefully folks more experienced in methylation will chime in soon.
     
    jepps and optimist like this.
  15. Gondwanaland

    Gondwanaland Senior Member

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    I was missing your optimist face around here :)
     
    WillowJ, optimist and Crux like this.
  16. Gondwanaland

    Gondwanaland Senior Member

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    I think you should start a thread in the methylation forum.
     
  17. Gondwanaland

    Gondwanaland Senior Member

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    These are increasing glutathione conjugation and perhaps depleting you from active B9 and B12.
     
  18. optimist

    optimist Senior Member

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    That's very kind of you :) Preferrably, we will all get out of here in due time!!!

    If this is a methylation issue, then perhaps I should...
     
    Gondwanaland likes this.
  19. optimist

    optimist Senior Member

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    I started this protocol after the onset of the nerve issues...
     
  20. Gondwanaland

    Gondwanaland Senior Member

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    Perhaps your treatment is going in the wrong direction
     

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