Hello, Started methylation treatment a while back and now I suddenly have some very weird symptoms. I have used cannabis for lyme symptoms for the past six years with great success but now suddenly I cannot tolerate it at all. I get severe chest pains, migraines, shortness of breath, insomnia, chills, and severe vasoconstriction and bad tinnitus. It is almost like an anaphylatctic shock reaction. I have tried it from 5 different sources and it is all the same. haven't used any in a few months now but even just the smell now sets of a severe reaction. I also cannot tolerate foods I have eaten for years like quinoa, potatoes, tomatoes, advocadoes, almond butter, peanut butter, and nuts in general. My tinnitus is going crazy all the time now. I have been taking TMG, methylfolate, methylcobalamin, l-carnitine fumarate. The only thing that really helps me now when I have this strange reaction is lots of benadryl and CLAY. I have even almost resorted to taken a benzo but have been able to resist so far (I was dependent years ago but am stressing so hard right now.....). I can't relax anymore because I am always having an allergic reaction and it is making my lyme or maybe candida flare up bad. I don't think it's candida because I've had that in the past and had lots of itching associated with it. I have tinnitus which I read could be a result of candida but it also can be a result of overmethylation, lyme, or allergy. Niacinamide (500mg) seems to make the tinnitus and other symptoms go away temporarily but it does not feel good for me to take in the long run because i feel it makes me more toxic. Also, grapefruit juice makes me feel great initially but then the next day my tinnitus goes nuts and i feel extremely bad. I have no idea what is going on now? I can't seem to be able to eat anything without having a severe reaction. I can't tell what is helping me and what is hurting me any more. Am i overmethylating? Undermethylating? I started tindamax & cat's claw after this reaction started because I am afraid the lyme is coming back in my brain . I don't understand if all this is due to methylation, lyme, or what!? Can anyone offer me any advice? I am completely miserable here. can't sleep, can't eat, and i'm about to lose my job due to exhaustion/insanity. i was able to manage my symptoms okay several months ago!