Well.. I do think it's very important to accept that CFS probably *isn't* a disease. The way people get ill, and the way they tend to get better, just don't appear very disease-like. A great many people do get better with rest alone (especially if they begin resting early enough), others get there once they've had mercury fillings removed, or identified food intolerances, or got B12 or magnesium levels up... There are documented cases of people completely resolving the condition with sweating or breathing protocols. It's one reason (amongst many) I'm so dubious of this recent focus on XMRV. (Correlation doesn't equal causation, and most people get well without antivirals.) Rest is quite different from just not being active, of course. Whenever I'm not actively doing something, I'm lying down with my feet up and really resting. I've had to find a balance between complete rest and light activity, and you really don't need a great deal of activity to avoid deconditioning. I'd say you're at much greater risk when your muscle mitochondria are failing, because then any exertion/exercise is going to be adding to the damage. But I certainly try to stay active enough to avoid blood clots or hypovolemia. I liken CFS to fixing bad finances. You've got x number of outgoings/burdens and y capacity to earn/produce energy/heal. (And the whole condition's a vicious circle. It's not something you ever actually HAVE or don't have, in my opinion.) What I've found is that every little decision I make, from dietary changes to supplement use to exertion, influences my trend. And there's a pretty narrow window on a lot of these things - which has become apparent through monitoring - where too little or too much can turn any recovery phase into a decline. So I have found I've got complete control over the condition, it's just VERY subtle and slow, on a day to day/week to week basis. I do think in stubborn cases, there's very likely to be a central lifestyle or nutritional factor which you've missed. Whether it's mercury, magnesium deficiency, some environmental toxin, magnetic fields, even, probably most likely for most of us: dietary intolerances. I'm eating little more than white rice and chicken right now. Should've been the first step I took, and my specialist said this but I've somehow managed to be really lazy on that one. The thing with charting it all is, even on a lot of supplements and with detox regimes, the improvement is WAY too subtle, even month to month, to notice. I said in that thread, in my case it works out to about 1.4 additional steps/day. Which sounds incredibly slow, but, then, when you're a PWC at 500 steps/day, you're pretty severely impaired; when you're at 1000 steps/day (without any acute symptoms), you're really half as ill. I took my exertion right back when I started on supplements, and kept it around 500-700 steps/day (before I was recording my results) for about 3 months to get my vitamin levels settled and wait until the fatigue eased a bit. Recently I crossed the 2,000 steps/day point, and where 1 1/2 years ago, seeing a friend for an hour would leave me exhausted and needing to lie down, I can now go out for 4-5 hours, have a few drinks, chat and not even look tired, then go home and not pay for it the next day. A huge difference really. But it's come down to balancing my regime to achieve that 1.4 additional steps/day. If I'd been on graded exercise, I'd have been aiming for, probably 5% improvement/week, at least, and then all I'd have done (as I have done 1000x before) is pushed myself into worse mitochondrial failure at some point, where the lines cross. Then gone backwards. At my worst I couldn't walk to the toilet. But back then I was generally much more up and down... Now I'm consistent, my body can heal and repair. I'm convinced there's no magic bullet; no point in time when you ever went from *not having* CFS to having it, and no point where you'll wake up one day without it. I just think it's a general state of cell-level health, and a number of common vicious circles we tend to get into. I also think as long as you're not actually getting worse, you're basically getting better. If the body can achieve any sort of homeostasis, it means your capacity to repair is matching the damage and interest rates. So then anything you do to help this process along is helping weigh things more in your favour. Exercise is always going to be a double-edged sword there. The only way you'll convince me it's a good idea is if you can show it lead to solid, long-term improvements in activity and reductions in symptoms... For me, it's always been short-term, then back at square one.