I am at about week 8. I have the co factors all in place. I have been on 1000mcg methyl b12 for the past 3 weeks and 600mcg of methyl folate. Last ight i increased the methyl b12 to a total 1250mcg, in 5 split doses through the day. I immediately got a symptom of body burning. Today I just feel awful- increased headaches and body itch with some nausea, plus my body aches have also increased. I wasnt feeling fabulous before i increased and now I feel worse. It is a bit hard to knwo with this protocol whetehr i should just have left alone at the 1000mcg dose or if i should keep pushing up the b12 in the hope that sooner or later I will feel better. I read with someone that they had start up for about 4 months and others it seems around 2-3 months....there is probably no answer to whether I should persist in going up with the b12 incrementally. I am just trying to find the best path to fast track the B12 start up and but not knock myself out. I wonder if others of you get more start up every time you increase the mb12 and how long does the start up from each dose increase last?....It is hard to believe hat the titration up from 1000 to 1250 is so noticable- but I do feel more unwell, no doubt about it! Who would believe that this protocol could be so tricky.