This is my update for the last 2 weeks.... I am at week 16, just had my 3rd infusion a few weeks ago. Feeling HORRIBLE... that little window of more energy has now closed again. Pain level is a good 8-9 daily from head to toe- neck the worst, OI issues bad, constant dull headache. Boyfriend came home from work today and pulled up his pant legs to show me his socks.. One black-One white - to ask with a grin on his face if I could manage to do some laundry soon... We both cracked up - but I really wanted to cry. Been doin lots of that lately too... I have been patient for ANOTHER 4 months trying this new route with the Rituxan. Have been on many routes and all I ever felt was "broke"... Hard to keep the faith but I am tryin. Doc K says patients usually respond around 22 wks, if they are going to. I used to be able to look around and see someone who had it much worse than I do...in regard to health... that is getting very difficult to do... Lately I have been trying to imagine something worse than this CRUEL illness...and I guess a burn victim in a burn unit would be horrific - but at least they would eventually heal and get out. At least they know there will be an END to their state of suffering... This wicked disease feels so terminal in spite of how absolutely determined I am... Wish I had something more positive to say... but just keepin it REAL!!