When a person gets methylation going, even only partially, the single most dangerous side effect is dropping potassium. In the absence of kidney damage which people usually know about and certain drugs that cause the potassium to accumulate, low potassium is the odds on favorite after staerting methylation. As methylation starts up, no ifs ands or buts typically, in a day or less with the active protocol, when those symptoms hit on the 3rd day typically or a little later, it's virtually always potassium. This can get dangerous, how quickly is the only question. I have had enough disturbing communications in the past couple of weeks to issue this repeating the warnings. From Pubmed - http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001510/ Hypokalemia Potassium - low; Low blood potassium Last reviewed: May 29, 2011. Hypokalemia is a lower-than-normal amount of potassium in the blood. Causes, incidence, and risk factors Potassium is needed for cells, especially nerve and muscle cells, to function properly. You get potassium through food. The kidneys remove excess potassium in the urine to keep a proper balance of the mineral in the body. Hypokalemia is a metabolic disorder that occurs when the level of potassium in the blood drops too low. Possible causes of hypokalemia include: Antibiotics (penicillin, nafcillin, carbenicillin, gentamicin, amphotericin B, foscarnet) Diarrhea (including the use of too many laxatives, which can cause diarrhea) Diseases that affect the kidneys' ability to retain potassium (Liddle syndrome, Cushing syndrome, hyperaldosteronism, Bartter syndrome, Fanconi syndrome) Diuretic medications, which can cause excess urination Eating disorders (such as bulimia) Eating large amounts of licorice or using products such as herbal teas and chewing tobaccos that contain licorice made with glycyrrhetinic acid (this substance is no longer used in licorice made in the United States) Magnesium deficiency Sweating Vomiting Symptoms A small drop in potassium usually doesn't cause symptoms. However, a big drop in the level can be life threatening. Symptoms of hypokalemia include: Abnormal heart rhythms (dysrhythmias), especially in people with heart disease Constipation Fatigue Muscle damage (rhabdomyolysis) Muscle weakness or spasms Paralysis (which can include the lungs) Signs and tests Your health care provider will take a sample of your blood to check potassium levels. Other tests might include: Arterial blood gas Basic or comprehensive metabolic panel Electrocardiogram (ECG) Blood tests to check glucose, magnesium, calcium, sodium, phosphorous, thyroxine, and aldosterone levels Treatment Mild hypokalemia can be treated by taking potassium supplements by mouth. Persons with more severe cases may need to get potassium through a vein (intravenously). If you need to use diuretics, your doctor may switch you to a form that keeps potassium in the body (such as triamterene, amiloride, or spironolactone). One type of hypokalemia that causes paralysis occurs when there is too much thyroid hormone in the blood (thyrotoxic periodic paralysis). Treatment lowers the thyroid hormone level, and raises the potassium level in the blood. Expectations (prognosis) Taking potassium supplements can usually correct the problem. In severe cases, without proper treatment a severe drop in potassium levels can lead to serious heart rhythm problems that can be fatal. Complications In severe cases, patients can develop paralysis that can be life threatening. Hypokalemia also can lead to dangerous irregular heartbeat. Over time, lack of potassium can lead to kidney damage (hypokalemic nephropathy).