At first it seemed that the vitamin IVs were very helpful and the benefits were noticed the day after in particular. But now I am wondering because over the past couple of years since taking them and nebulizing glutathione and magnesium and B12, it seems that things are worse than ever. It's confusing. Makes me wonder if too much magnesium or one of the vitamins could be causing the terrible digestive problems that have arisen. Would be interested if others have noted a downhill trend over a couple of years after starting this. Thanks.