Does anyone know how vitamin D leaves your body? I found this Vitamin D synthesis pathway: http://www.wikipathways.org/index.php/Pathway:WP1531 Which seems to show it going through CYP24A1 to convert to 24,25-OH Vitamin D. But what happens to that? Is that excreted through the urine? Are there other pathways similar to estrogen where it goes through various Phase I and Phase II detox? There are several studies that show a link between Vitamin D and GSH levels, so I'm wondering if it uses glutathione to detox. Reason I am asking is because estrogen induces my symptoms and basically makes me crash-- so I'm hypothesizing that my symptoms are possibly related to low glutathione/redox-cycling as described in some previous estrogen-related threads. But vitamin D also induces my symptoms and makes me crash. I'm trying to figure out if there is a link there somewhere and whether it could be related to detoxification or not. If anyone has any ideas, I'd love to hear them. I realize that most people actually do better on Vitamin D, so there is probably something unique to me that is screwed up. My parathyroid levels were normal when checked and I have already considered lupus and sarcoidosis.