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Vitamin C May Improve Circulation in Postural Tachycardia Syndrome

Discussion in 'Other Health News and Research' started by ggingues, Nov 16, 2011.

  1. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
  2. Sasha

    Sasha Fine, thank you

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    Thanks, GG - I've got OI, not sure if it's low-flow POTS. This is an interesting article. Does anyone know what the IV dose of Vit C in this study would correspond to as a dose of oral Vit C?
     
  3. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    I didn't understand what the IV dose was? Help? I have taken a lot of IV vit C infusions and never noticed its affect on OI. I don't have POTS though, but NMH.

    Sushi
     
  4. svetoslav80

    svetoslav80 Senior Member

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    You didn't understand because they didn't tell. 10 mM (millimolar) is a measure for solution concentration and not quantity. And they didn't take it intravenous but intradermal (if that matters).
     
  5. taniaaust1

    taniaaust1

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    Thanks heaps for posting this study here, Ive copied it and will take it to the specialist with me when I go and see one for the POTS next month.

    I too dont know if I have "low flow" POTS or not thou I assume I may thou I dont get many of the signs I have low blood flow anymore so its all rather confusing.

    I wonder how much longer vitamin C stays in the body with this method of delivery compared to taking it via mouth. (I know when taking it by mouth one basically pees it right out so hence you need more then one dose per day, several doses are far preferable).
    ....

    Im trying to understand what this delivery procedure exactly is

    "A 25 gauge needle is inserted into the dermal space and exits the skin approximately 15 mm distant. The microdialysis catheter is inserted into the lumen of the needle, and withdrawn so that the dialysis membrane is 10 mm from the point of insertion. Once the membrane is placed, the needle is withdrawn. Multiple catheters are typically used but must be spaced at least 6 cm apart throughout all procedures and are taped in place. "

    Dont know if this study did it exactly like that quote above from . http://www.nymc.edu/fhp/centers/syncope/microdialysis.htm
    (that microdialysis page also does have links to POTS stuff so I assume this gives us a good idea of what the deliverly procedure).
     
  6. svetoslav80

    svetoslav80 Senior Member

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    "To date, microdialysis is the only sampling technique that can continuously monitor drug or metabolite concentrations in the extracellular fluid of virtually any tissue" (cyte from wiki - http://en.wikipedia.org/wiki/Microdialysis).

    So they used this method because it's the only way to administer and monitor vitamin C concentration simultaneously, and not because it's effective or something. Intravenous and intramuscular are much more effective, as I remember 70 times more vitamin C comes to blood compared to oral administration.
     
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  7. Dolphin

    Dolphin Senior Member

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    Ascorbate improves circulation in postural tachycardia syndrome-Stewart et al (Vit C)

    Apologies if this has been posted before.

    Dr. Teitelbaum has a piece on it:
    * I gave each sentence its own paragraph
     
    allyb likes this.
  8. allyb

    allyb Senior Member

    Thank you Dolphin, any study into alleviating the awful and debilitating symptoms of pots gets my vote as I suffer terribly.

    But :Sign Help:, can anyone interpret this study in plain speaking please? What did they do and how? And what might it mean for us potsy people in terms of taking Vit C?

    Grateful
    allyb
     
  9. Dolphin

    Dolphin Senior Member

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