Justy raised the interesting question on a thread about the best type of Vitamin C. She asked whether it's wise to let your choice of dose be guided by your bowel tolerance limit. I had assumed for years that it was, because that was what I was reading - that the idea was to titrate up until you couldn't tolerate it and then cut back by 10% and hold at that dose. I thought it was the body taking all it needed and rejecting the rest. Using that principle, during my first bout of ME (several years bedbound) I titrated up to 45g/day. Now, after a period of remission I'm mostly housebound/bedbound and titrating up from zero because Vitamin C supplementation is part of Freddd's b12 protocol, which I'm following. Justy warns about kidney stones from high doses of Vit C, for example, so it's not harmless. Any views on the question of whether the bowel tolerance limit is the limit to go for? And if not, what is a reasonable dose? Or a sensible strategy for arriving at one?