1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
Discuss the article on the Forums.

visit to doctor - discussion of nickel DNA adduct results

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by globalpilot, Feb 23, 2011.

  1. globalpilot

    globalpilot Senior Member

    Messages:
    594
    Likes:
    214
    Ontario
    Hi Rich and group,

    I saw my CFS doctor yesterday. We discussed chelation due to the nickel DNA adduct found on my mitochondrial superoide enzyme DNA as well as on my mitochondiral translocater protein.

    He said it doesn't necessarily mean elevated body burden of mercury. He said it couldmean either it is elevated or that there is inflammation causing the mercury to stick to the adduct.

    Also, I was wondering myself how well you can translate the results of a small blood sample tothe entire body ? That is, if a molecule of nickel shows up in the sample, could that just be coincidence ? How do we know the metals adducted tothe DNA in my case and to the translocator protein are an issue throughout the body ?

    Does anyone have any insights on this.

    Regards,
    GlobalPilot
     
  2. richvank

    richvank Senior Member

    Messages:
    2,717
    Likes:
    758
    Hi, globalpilot.

    (I'm assuming you meant to discuss nickel throughout your post, and that you didn't mean to switch to mercury in your second paragraph.)

    I suspect that having nickel bound to DNA and the mito translocator protein in your neutrophils does mean that you have an elevated body burden of nickel. Inflammation could contribute to causing a higher body burden of nickel, in that inflammation involves production of oxidative stress, oxidative stress places a demand on glutathione, tending to lower it, and low glutathione would allow buildup of nickel if you were exposed to it, such as from stainless steel food processing equipment and cookware.

    The reason why a blood sample is representative of the body as a whole is that the blood is constantly circulating, and all the cells of the body communicate with it via the extracellular fluid and the lymph system. In addition, there is the dynamic equilibrium concept in chemistry, in which molecules are continually forming bonds and breaking them, so that on the average, what is in the blood will represent what is in the tissue cells fairly well. There are some components that are not evaluated well by blood samples, however, such as magnesium. Most of the magnesium in the body is in the bones and in the tissue cells. Blood serum and even red blood cell testing does not represent the body's magnesium status well. Another one is mercury. Mercury stays in the blood for several weeks, but after that, it is sequestered in the tissues, especially in the kidneys, so blood testing will not give a good indication of the body burden of mercury from chronic exposure. But in the case of nickel, blood testing should be pretty good, because nickel does not get strongly sequestered, as far as I know. The neutrophils have a lifetime of only a few days, so the testing done by AcumenLab on neutrophils should reflect the current levels of nickel.

    Best regards,

    Rich
     
  3. aquariusgirl

    aquariusgirl Senior Member

    Messages:
    950
    Likes:
    91
    i think poster carolxyz said she got her nickel down by taking 500mg of methionine.
    this is what john mclaren howard recommends.
    pls double check the dosage.. I am speaking from memory.
     
  4. globalpilot

    globalpilot Senior Member

    Messages:
    594
    Likes:
    214
    Ontario
    Hi Rich,

    Thank you for this explanation.

    I am confused by one thing. In your second paragraph you state you think the test may indicate an elevated body burden. But in the last you indicate the testing done by Acumen reflects current levels. Do you mean current exposure ? These seem to be contradictory issues. Am I reading this incorrectly ?

    Regards,
    GP
     

See more popular forum discussions.

Share This Page