Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroidit

Discussion in 'Other Health News and Research' started by Bob, Oct 10, 2012.

  1. Bob

    Bob

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    Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroiditis

    Elisabetta Caselli et al
    October 4, 2012
    PLoS Pathog 8(10): e1002951.
    doi:10.1371/journal.ppat.1002951
    http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002951


    Abstract
    Hashimoto's thyroiditis (HT) is the most common of all thyroid diseases and is characterized by abundant lymphocyte infiltrate and thyroid impairment, caused by various cell- and antibody-mediated immune processes. Viral infections have been suggested as possible environmental triggers, but conclusive data are not available. We analyzed the presence and transcriptional state of human herpesvirus 6 (HHV-6) in thyroid fine needle aspirates (FNA) and peripheral blood mononuclear cells (PBMCs) from 34 HT patients and 28 controls, showing that HHV-6 DNA prevalence (82% vs. 10%, p≤0.001) and viral load were significantly increased in FNA from HT patients, and thyrocytes from HT FNA displayed a 100-fold higher HHV-6 DNA load compared to infiltrating lymphocytes. In addition, while HHV-6 was strictly latent in positive samples from controls, a low grade acute infection was detected in HT samples. HHV-6 variant characterization was carried out in 10 HT FNA samples, determining that all specimens harbored HHV-6 Variant A.
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