1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. Part 1 of a 2-part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS. Part 1 focuses...
Discuss the article on the Forums.

Viral infection may trigger Crohn's disease in susceptible individuals

Discussion in 'Other Health News and Research' started by Waverunner, Feb 8, 2014.

  1. Waverunner

    Waverunner Senior Member

    Messages:
    991
    Likes:
    828
    If you ever asked yourself, if a viral infection is able to cause a chronic and seemingly unrelated disease in susceptible individuals, here could be the answer.

    http://www.ncbi.nlm.nih.gov/pubmed/20602997

    Abstract
    It is unclear why disease occurs in only a small proportion of persons carrying common risk alleles of disease susceptibility genes. Here we demonstrate that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice. This virus-plus-susceptibility gene interaction generated abnormalities in granule packaging and unique patterns of gene expression in Paneth cells. Further, the response to injury induced by the toxic substance dextran sodium sulfate was fundamentally altered to include pathologies resembling aspects of Crohn's disease. These pathologies triggered by virus-plus-susceptibility gene interaction were dependent on TNFalpha and IFNgamma and were prevented by treatment with broad spectrum antibiotics. Thus, we provide a specific example of how a virus-plus-susceptibility gene interaction can, in combination with additional environmental factors and commensal bacteria, determine the phenotype of hosts carrying common risk alleles for inflammatory disease.
    maryb likes this.
  2. Legendrew

    Legendrew Content team

    Messages:
    531
    Likes:
    665
    UK
    I'm not shocked by this as viruses have been long implicated as triggering events for many autoimmune diseases, it's nice to see the reason for this is being explored through studies such as this - I am however a little wary of the animal model being used as things tend to look really promising yet don't transfer smoothly into human biology.
  3. Waverunner

    Waverunner Senior Member

    Messages:
    991
    Likes:
    828
    True. Still we have to wonder why we lack antivirals and why most doctors don't seem to care about most viruses, despite their possible implication in so many diseases.
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,102
    Likes:
    4,348
    australia (brisbane)
    It would be interesting to see the state their immune function is like nk and t cell function as well as compare this to other auto immune conditions as well as cfsme.

    I think the simple explanation of autoimmune conditions is the body attacks itself. This just doesn't really make sense to me. I wonder if auto immune illnesses are just viruses intergrated into our dna much like ihhv6. So it may appear the immune system is attacking our bodies but in reality the immune system is trying to kill the infected dna/cells??

See more popular forum discussions.

Share This Page