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Viral infection may trigger Crohn's disease in susceptible individuals

Discussion in 'Other Health News and Research' started by Waverunner, Feb 8, 2014.

  1. Waverunner

    Waverunner Senior Member

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    If you ever asked yourself, if a viral infection is able to cause a chronic and seemingly unrelated disease in susceptible individuals, here could be the answer.

    http://www.ncbi.nlm.nih.gov/pubmed/20602997

    Abstract
    It is unclear why disease occurs in only a small proportion of persons carrying common risk alleles of disease susceptibility genes. Here we demonstrate that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice. This virus-plus-susceptibility gene interaction generated abnormalities in granule packaging and unique patterns of gene expression in Paneth cells. Further, the response to injury induced by the toxic substance dextran sodium sulfate was fundamentally altered to include pathologies resembling aspects of Crohn's disease. These pathologies triggered by virus-plus-susceptibility gene interaction were dependent on TNFalpha and IFNgamma and were prevented by treatment with broad spectrum antibiotics. Thus, we provide a specific example of how a virus-plus-susceptibility gene interaction can, in combination with additional environmental factors and commensal bacteria, determine the phenotype of hosts carrying common risk alleles for inflammatory disease.
     
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  2. Legendrew

    Legendrew Content team

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    I'm not shocked by this as viruses have been long implicated as triggering events for many autoimmune diseases, it's nice to see the reason for this is being explored through studies such as this - I am however a little wary of the animal model being used as things tend to look really promising yet don't transfer smoothly into human biology.
     
  3. Waverunner

    Waverunner Senior Member

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    True. Still we have to wonder why we lack antivirals and why most doctors don't seem to care about most viruses, despite their possible implication in so many diseases.
     
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    australia (brisbane)
    It would be interesting to see the state their immune function is like nk and t cell function as well as compare this to other auto immune conditions as well as cfsme.

    I think the simple explanation of autoimmune conditions is the body attacks itself. This just doesn't really make sense to me. I wonder if auto immune illnesses are just viruses intergrated into our dna much like ihhv6. So it may appear the immune system is attacking our bodies but in reality the immune system is trying to kill the infected dna/cells??
     

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