This is a concise review of a supplement called vinpocetine which is derived from the periwinkle plant. The article is geared toward the scientifically trained reader but seems readable nonetheless. Vinpocetine is an inexpensive supplement with strong evidence of neuroprotective effects in cerebrovascular disease. I have been taking it for six months with no side effects (10mg/3xday), since an abnormal brain MRI in March 2011. A lot of my worst cognitive symptoms improved (especially short-term memory) when I started taking it. I began b12 IM about the same time, so I can't completely credit it with anything. But based on the research, cost and safety profile, it's been in my supplement regimen. Google scholar shows all the research. The recent PNAS paper into its inhibitory effects on NF-kB inflammation is especially interesting.