I'm a 37 year old guy. I have mostly recovered from AFS (adrenal fatigune syndrome) by following Dr. Lam's protocol of taking vitamins, doing yoga, meditation, low carb diets, etc. But I still have low energy. I would describe my present condition as mild CFS. The apparent cause of my CFS is oxidative stress after 8 years of an extreme lifestyle (workaholic, athletics, partying). During this time I also used (not abused) stimulant ADD medication to help me work and study. My main CFS symptoms are photosensitivity & PEM. I am fairly strong - I work 35 hours a week, do hot power yoga, go on dates, etc. But on the evenings and weekends my mitochondria can't produce enough energy to do "extra" activities. I have to lay around and recover and can't live a normal life - only working, housework, exercise, rest - "surviving." I tolerate Vitamins C, D, E and Bs... magnesium, ashwaghanda, licorice, thyroid glandular, astaxanthin... very well. I tolerate most supplements at normal doses except mitochondrial supplements. I seem to respond well to liposomal glutathione and glutathione promoting substances (NAC). the standard CFS supplements produce more energy in my body... but they are many intolerable for one reason or another. D-ribose - 750 - 1500mg works but is very short acting, causes unpleasant "crash" when it wears off very suddenly. The standard 5 gram dose is unbearably overstimulating. Acetyl-L-carnitine - 500mg makes me anxious and WIRED... pacing, shaking, tweaking out. Yuck! NADH - 2.5mg is tolerable and works occasionally, but taking it on consecutive days causes "tingling" in my extremities, and a "something just isn't right" feeling that is hard to describe. Swanson Cardioplex - On Sunday at 10 am I took this low dose, Ribose-Carnitine-Q10-Magnesium pill and it shot my energy WAY up... enough to get me working on household projects. But by 3pm I totally ran out of steam. I was flagging, dragging and super depressed. I'm sure a re-dose would have fixed me, but I didn't like how fast it dropped off. NAC - 600mg gives a gentle uplift in mood, libido, energy for several hours. Works as described, no bad effects. But not really strong enough to get my energy levels close to normal. CoQ10 - Yesterday I took 25mg of liquid in the AM and it was AMAZING. I felt loads of energy rushing through my body, full of vigor. But by 5p.m. I was feeling anxious, overloaded & uncomfortable. It was a little hard to fall asleep. I woke up feeling a little bit frazzled (similar to over-exertion feeling) the next morning. Today I took 12.5mg of CoQ10 formula and it seems to be effective, but not overwhelming. I feel very good, spring in my step, positive, even caught myself humming & signing. I am really hoping that I can go "low and slow" with Q10 and tolerate it. Please God! Based on my case history above - Can anyone please help or interpret why I may be having this sort of sensitivity reaction, what this means, what I should do or try?