Hi, I did a pregnenolone and DHEA-testing and both came back really low: Pregnenolone-S 13,7 ng/l (70-250) DHEA-S 49 ng/dl (100-300) Cortisol 103 ng/ml (50-250) My sex hormones are also normal (estrogene, progesterone), testo is always in the more lower to very low range. I consulted 2 doctors and both were shocked about the numbers as I am only 38 years old (female). They say these values are only seen in very old and aged people. One of the doctors suggested failure of the adrenal cortex, but the other one told me the cortisol level is still in the normal range, so no adrenal failure. I suffer from extreme exhaustion and I am never tired. But my body feels broken and injured. And I cannot sleep, no single night. So doctor told me to take preg and dhea but is also afraid of making my insomia worse as pregnenolone is a potent gaba-antagonist and insomnia and headaches are common due to activation of certain receptors. As pregnenolone is manufactured in the mitochondria, can this be the problem? Pregnenolone steal does not seem the cause because I have no elevated cortisol and my sex hormones are all in the low-normal range. Also I am afraid of getting addictec to pregnenolone as several members reported some kind of "withdrawal". I am not a typical cfs sufferer (no viral onset), but share many symptoms like bone crushing exhaustion, insomnia, food intolerances, mast cell activation, intolerance to most medications and supplements, temperature dysregulation and other things. If anybody has some suggestions, informations/experiences in this topic, I would be so grateful. I really feel a bit lost on this. Thank you!