I was a bit more light-headed than usual all of yesterday, but was able to sit up for a couple hours before laying down. Then after making dinner (10 minutes standing up + attempted adrenaline rush when my fiance appeared at the window), I was unable to sit up at all. After laying down a while with no improved ability to sit, I finally ate a bit while laying down mostly. I'd hoped it would improve a bit after a good night's rest, but despite sleeping well, I'm still having big problems. I only managed about half an hour of sitting up before needing to lay down again. Usually I can sit up 3-6 hours in the morning before I need to lay down for an hours, so I'm pretty sure I'll have to lay down pretty much all day today. I'm worried that this isn't a temporary thing, but rather a progression of my OI. I think my light-headedness is related to fluid loss preceded by swelling (water moving from blood to other tissues?), since the light-headedness starts some hours or a day before the excessive urination. My weight dropped has 2 pounds in the past 24 hours, despite eating plenty and drinking extra water and electrolytes. Because of the attempted adrenaline rush, and my history of low epinephrine and norepinehprine, I'm worried that depletion of epinephrine and norepinephrine may be causing my current inability to cope with sitting upright. I was also off my supplements for about a week (until Wednesday), and had two vials of blood taken for testing on Monday. I get a bit hot and sweaty when upright too long, something that didn't happen before. I also start breathing more rapidly with my mouth open after laying down when I start feeling horrible while sitting up. My legs feel very heavy when I try to walk, and my arms also if I try to use them after sitting up too long. Walking 15 feet to the bathroom is a bit scary because I don't feel like I can control my legs well enough to keep them supporting me. I also have mild diarrhea this morning. Any suggestions, other than water, electrolytes, and laying down all day? I don't think raising dopamine would help, because that tested high when epinephrine and norepinephrine were low. I also tried licorice in the past with no effect, though that was in candy form, not pure licorice. Is there a non-prescription way to raise epinephrine and/or norepinephrine? Also, my symptoms (low pulse pressure, no increase of heart rate) are indicative of NMH, with no POTS involvement.