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VDR Taq alleles

dbkita

Senior Member
Messages
655
So I recently got my 23andMe results and used Genetic Genie to convert them to the Yasko panel. I will post my results in another thread at some point.

My question though is as follows.

For the VDR Taq SNP rs731236 I have the AA homozygote combination. According the Genetic Genie this is ++ in the Yasko notation.

But when I look here:
http://browser.1000genomes.org/Homo...7-48239257;v=rs731236;vdb=variation;vf=586368

The reference is the A allele and the AA combination is greater than 50%!

But according to Yasko this is the risk allele?

I am confused. My questions is which allele leads to reduce dopamine production? The A or the G?​
Anyone have any thoughts?​
 

dbkita

Senior Member
Messages
655
According to Dr Yasko (and Genetic Genie) the AA allele is considered ++ and low dopamine (with higher methyl donor tolerance). So I am confused since the GG allele is only 8% or so of the population.