I would not be surprised if this was the underlying problem in most of us. Regardless of the cause of the beginning of our fatigue, most of us probably have a problem with orthostatic intolerance/hypotension from this. http://www.ncbi.nlm.nih.gov/pubmed/8475696 Gonna try out some therapy (low dose) and see if I benefit. I do benefit when upping my florinef dose temporarily. In the end my fatigue is a fluid dynamic problem. Those of us like me taking hydrocortisone and multiple hormones may see temporary improvement because virtually every hormone has the power to increase blood pressure and whatnot. We shall see.