So as you all know I have been posting in my signature that I have been cured. I attribute all of this to hormone therapy. Hypothyroid, hypocortisol, Vasopressin deficiency, low aldosterone, low testosterone. And probably dhea deficiency during athletic stress. I have enjoyed weight lifting and tend to push myself in the gym quite a bit. Perhaps the reason it took me a long time to cure myself (other than the fact that 19/20 doctors I dealt with were totally clueless including endocrinologists), is that ADH is such a tricky hormone to test and regulate. First of all I would say of 20 endocrinologists maybe one skillfully knows how to test for diabetes insipidus. The crazy thing is that I had a private test done for ADH levels and mine came back 3.5 in a 0-4.0 reference range. Yet I am still pissing all day. I used to drink gallons of water (literally) everyday for a period of months and my thirst mechanism finally gave out. But I continued peeing 2x the volume I took in. Another member here suggested I measure my urine volume. So I did that and every time my output was twice my input through the course of a day. It doesn't take an Einstein to realize that day after day this is going to produce chronic dehydration. There are several forms of DI, yet apparently my body is capable of making ADH, yet apparently I respond to vasopressin therapy. It is tricky because I also have an aldosterone level of 0. So if I take too much vasopressin I am at even greater risk than most for depleting sodium. So I really have to watch my fluid intake after taking half a pill of vasopressin in the AM and before bed. Drug toxicity and dizziness have been some of the most salient problems of mine next to my frequent urination. I will take a drug in a quarter of an amount most people will take and will get all of the side effects. lol I attribute this to hypovolemia causing my liver not to function properly. I cannot emphasize how important it is to measure your urine volume, because if you are constantly pissing out more than you are taking in you are doing to be chronically fatigued. Most endos would see an ADH reading of mine and dismiss me. Though it could have been a mixed up test I suppose. A more accurate way to measure for DI is probably comparing the solutes (electrolytes) in the blood to that in the urine at the same time. (thanks to CBS for sharing this) Vasopressin is tricky though because you can also drink too much water and end up just as fatigued on it. This could also explain my high histamine/low histidine levels as histamine triggers ADH release.