http://www.iacfsme.org/LinkClick.aspx?fileticket=EFIrm+uCnkM=&tabid=142 In page 46 is an interesting work of Shoemaker with VIP . They had a symptom reduction in all patients with not adverse effects. The VIP was administered intranasally four times a day. "Treatmet with VPI restored clinical functioning in a cohort of patients with severe CFS illnes". I dont know if this is a very expensive treatment,but I hope can be a good treatment in the future.