Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Variations of the perforin gene in patients with multiple sclerosis

Discussion in 'Multiple Sclerosis' started by nanonug, May 9, 2012.

  1. nanonug

    nanonug Senior Member

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    Variations of the perforin gene in patients with multiple sclerosis

    Possibly pathogenic polymorphisms available on 23andme are:
    • rs28933374 (P345L) - risk allele 'T'
    • rs28933375 (A252S) - risk allele 'C'
    • rs28933376 (T435M) - risk allele 'T'
    • rs35947132 (A91V) - risk allele 'A'

    Additional info available on Pubmed's PFR1 Variation Iewer.

    By the way, I am heterozygous for rs35947132 (A91V), one the polymorphisms mentioned in the study. There are a bunch more studies on Pubmed regarding these and other polymorphisms.
     

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