The Call for Opposition: Challenging the P2P and IOM Processes
In our second article on how to react to the publication of the draft P2P report, Gabby Klein provides her view of why she and a large group of advocates and patients are continuing their protest of the government’s ongoing control and manipulation of our disease via their processes...
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Variations of the perforin gene in patients with multiple sclerosis

Discussion in 'Multiple Sclerosis' started by nanonug, May 9, 2012.

  1. nanonug

    nanonug Senior Member

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    Variations of the perforin gene in patients with multiple sclerosis

    Possibly pathogenic polymorphisms available on 23andme are:
    • rs28933374 (P345L) - risk allele 'T'
    • rs28933375 (A252S) - risk allele 'C'
    • rs28933376 (T435M) - risk allele 'T'
    • rs35947132 (A91V) - risk allele 'A'

    Additional info available on Pubmed's PFR1 Variation Iewer.

    By the way, I am heterozygous for rs35947132 (A91V), one the polymorphisms mentioned in the study. There are a bunch more studies on Pubmed regarding these and other polymorphisms.
     

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