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Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

Discussion in 'Other Health News and Research' started by adreno, Aug 15, 2017.

  1. adreno

    adreno PR activist

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    https://www.ncbi.nlm.nih.gov/pubmed/27133167
     
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  2. adreno

    adreno PR activist

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    Write-up:

    http://www.cell.com/cell-host-microbe/pdf/S1931-3128(16)30161-5.pdf
     
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  3. Helen

    Helen Senior Member

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    "Therefore, their lipopolysaccharide (LPS) exposures arose primarily from Bacteroides rather than from Escherichia coli, which is a potent innate immune activator."

    "We show that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance..."

    from the abstract
    _______

    @adreno, thanks. Interesting facts and findings about the role of Bacteroidetes producing LPS and possible role in allergies and autoimmunity.

    KDM tests for LPS and the composition of the microbiome. His gut treatments are based on these (among others). Maybe he is just too early into this area to be understood according to the discussion in this thread?

    http://forums.phoenixrising.me/inde...ent-avelox-400mg-for-overgrowth-in-gut.53443/
     
    Last edited: Aug 15, 2017
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  4. msf

    msf Senior Member

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    He also finds that Bacteriodes are commonly increased in his patients, as did Lipkin in his recent gut study.
     
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  5. msf

    msf Senior Member

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    Also, this study shows how much geography affects the gut, which might explain why KDM´s patients seem to have higher levels of Bacteriodes than those in the Lipkin study.
     
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  6. adreno

    adreno PR activist

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    Yes. I have seen some improvements using Mutaflor (e. coli). I believe many PwME could benefit from that.
     
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  7. pattismith

    pattismith Senior Member

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    Galactose and Fucose are beneficial to the E.Coli growth.

    it would be nice to know how to inhibit our Bacteroides, and also how to activate our Prevotella (Prevotella histicola have shown anti inflammatory activity and protection against RA and MS in mice)
     
  8. adreno

    adreno PR activist

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    Have you seen Ken Lassesen's series on the Lipkin findings? He goes through each bacteria and how to decrease/increase them:

    https://cfsremission.com/2017/04/29/series-on-ian-lipkin-research-results/
     
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  9. pattismith

    pattismith Senior Member

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  10. arewenearlythereyet

    arewenearlythereyet CURRENTLY MODERATED FOR NOT BEING SERVILE

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    Just to clarify bacteriodes is the genus not the species. It's highly unlikely that they are all harmful since the species within this genus make up over 20% of total normal gut flora . It's too general to say you want to wipe out all of them and it's too general to draw too many conclusions until you have the species and the particular strains mapped out in detail. Just saying. The following may explain better

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/#!po=1.25000
     
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