My new CFS doc has started me on Valtrex (1,000 mg) for 4 months followed by herbal antivirals. I'm just wondering if too soon. I've read that inflammation in the gut needs to be addressed first. I haven't even started on a B vitamin protocol. Is my body ready for this? Anyway, I'm scrambling to read as much as I can about antiviral treatments. Reading @Matt.C thread has been very helpful. I read the Marshall Protocol but this seems to be more of an anti bacterial treatment. A 4 year treatment seems to suggest that those same being treated have severe inflammation and autoimmunity. What are the tests to determine if one falls under this category? Although I'm not (as yet) following this protocol, should I avoid vitamin C? Re: IRIS. I'm not sure I understand this. Is it an inflammatory response caused by a reactivation of your immune cells? Has anyone tried Byron White formulas? Day 4- gut pain and diarrhea.