Does anyone else have trouble sleeping due to Valcyte? Have you found any way to solve that problem? A few months ago I started taking Valcyte 1800 mg (900 mg 2x per day). After about 2 weeks it seemed to really kick in and give me tons of energy. I had trouble sleeping, but found that a tiny dose of melatonin (0.5 mg) solved that problem for me. I felt wonderful. Overall I thought I was 95% better and felt like I finally found the treatment that would keep me healthy long term. Now fast forward about 2 months. The small melatonin doses are no longer enough to help me fall asleep. Larger doses can get me to sleep but don't keep me asleep. I wake up at 3 am or 4 am and can't get back to sleep for another hour or two. Even though I can get back to sleep, I wake up feeling drained because it's not a deep sleep. During the day I'm back to feeling foggy, working is difficult, and I get frustrated and sad about it. When I discussed the problem with my CFS doctor, he told me to drop down to 900 mg (morning only). Within two days I was spending half the day in bed extremely sleepy. I hoped it was just a temporary withdrawal effect so I stuck with this plan. But 10 days later I was still struggling to function. Sleep was way better, but overall I was worse off. The doctor and I agreed that I should step back up to 1800 mg, and I felt improvement the same day. Within the week I felt mentally very clear again. But then the sleep issues set in again and I started to feel worse. Maybe it's possible that my worsening is due to Valcyte side effects. But so far I'm keeping my fingers crossed that the loss of benefits / worsening is simply due to the ongoing sleep issues. I'm hoping that if I can solve the sleep problem that I'll feel good again. I plan to discuss the need for a sleep aid with my psychiatrist next week. I'm interested to know what has worked for other people on Valcyte.