So I have been on Valcyte for a little over 3 months now and I am feeling discouraged because, after a brief improvement (placebo effect?), I have gotten back to how I felt before I started taking it. Well, that's not completely accurate. OI has improved and I am sleeping better, but I think the sleep is more due to sleep meds and I still rarely feel rested. Back and leg pain are consistantly bad, but I am not taking anything for pain right now. Am back to crashing on the couch every afternoon after going a few weeks not having to do that. I know it can take 6 months or a year to see results, but I am feeling very depressed right now because I was hoping to see gradual improvement. Currently taking valcyte 900mg, prozac 30mg in the morning. Seroquel 25mg at night (50mg on really bad nights, but then I literally can't get out of bed in the morning). Also xanax .25 a couple times a week for sleep and/or anxiety. Tried micronized zeolite and chlorella for detox, but neither seemed to help. Also taking various vitamins/minerals. Getting CBC and liver function tests monthly and they have all been normal.