Hello - I posted this in the methylation board but thought maybe it should've been here. Does anyone know of potential risks from vaccines for the A1298C mutation and it's affect on mast cells? I have been really struggling for the past few months, but I just figured out another piece of the puzzle. I had 3 vacinnes RIGHT before these problems started. Ironically, it was just after I started the methyl supplements. Perhaps the combo was not good for my body. If you know my story, I began treating for MTHFR (A1298C mutation) by a practitioner who doesn't understand the whole issue and haven't been the same since. I reached a point where I couldn't tolerate ANY food b/c it led to difficulty breathing and head pressure. I also developed multiple chemical sensitivity. The past 4 wks have been hell. I've only been able to eat about 5 foods. After seeing multiple drs and one making a connection to mast cells/histamine, I think this is causing my problems. I've read one person state that vaccines can cause the mast cells to become overactive, leading to an increase in histamine. I think this could be the cause for my problems. Is anyone aware of this connection? I also want to determine if I have a mast cell disorder or was this just a one-time deal of mast cell problems caused by the vaccines? But it has been 8 months, and I"m not better, in fact much, much worse.