From a New York Times Article http://well.blogs.nytimes.com/2009/07/15/going-all-out/ Interesting article on how the brain appears (subconsciously) to effect muscle activity. Reward works! It actually relaxes the muscles; they didn't feel less fatigue but their muscles could actually work harder- the brain relaxed the muscles. Could the brains of ME/CFS patients be saying STOP! all the time? Dr. Light's thesis in a nutshell - but he thinks he's uncovered evidence that this part is totally screwed up in ME/CFS. There is evidence of reduced neural input to the muscles in CFS; another study with no (or little) followup - a frigging crime. “I think the training effect of this theory is potentially very profound,” Tucker says. “Training is no longer simply an act of getting the muscles used to lactate or teaching the lungs how to breathe harder.” It’s also about getting your brain to accept new limits by pushing yourself, safely. “Once your brain recognizes that you’re not going to damage yourself,” Foster says, “it’ll be happy to let you go.” My sense with myself is that my brain is saying No! again and again. It basically constricts my muscles - freezes them up. Magnify this theory a couple of magnitude and I wonder if you find a model for ME/CFS.