I remember @Freddd saying that it was helpful to see new symptoms coming up in the methylation protocol as clues regarding what the body is doing / lacking. Sinus symptoms and some gut reactions I was able to get under control titrating doses/ratios of B12 and folate. The new symptoms I'm trying to get a handle on (not because they are particularly bothersome but because I wondered if they might be pointers to another "lack" in the body) are hair loss and aching joint in my fingers, hands and toes (kind of arthritis feeling). Anyone have any ideas what these could be linked too? I wondered if the hair loss might be lack of copper due to my increase in zinc but adding that in hasn't changed anything.