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Using gene expression signatures to identify novel treatment strategies in gulf war illness

Discussion in 'Other Health News and Research' started by Bob, Jul 14, 2015.

  1. Bob

    Bob

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    Open Access.

    I came across this via Tom Kindlon on Twitter.

    This has an extra element of interest for us, because I believe that Klimas and Broderick are using the same research techniques for ME/CFS, albeit with limited funds. They're trying to find drugs that can be repurposed for GWI illness in this paper, and ME/CFS in other similar research. There is a video, elsewhere on the forum, in which Nancy Klimas discusses this research.



    Using gene expression signatures to identify novel treatment strategies in gulf war illness
    Travis J.A. Craddock, Jeanna M. Harvey, Lubov Nathanson, Zachary M. Barnes, Nancy G. Klimas, Mary Ann Fletcher and Gordon Broderick
    9 July 2015
    BMC Medical Genomics 2015, 8:36
    doi:10.1186/s12920-015-0111-3
    http://www.biomedcentral.com/1755-8794/8/36/

     
    Last edited: Jul 14, 2015
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  2. SDSue

    SDSue Southeast

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    Fascinating and inspiring charts from the study. Looks like Klimas et al are hard at work determining the direction of future drug trials based on other known diseases with similar gene expression. There’s so much information here!





    s12920-015-0111-3-3.jpg





    s12920-015-0111-3-2.jpg
     
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  3. Simon

    Simon

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    This is a fascinating, perhaps brilliant approach.
    Full marks for using sedentary controls but I do wonder if such a small sample size can support those findings.
     
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  4. Bob

    Bob

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    lycaena, Sasha, SDSue and 3 others like this.
  5. SOC

    SOC Senior Member

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    Wish I had the slightest clue what any of those figures mean. I'm very impressed by them, though... whatever they mean. :p
     
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  6. SDSue

    SDSue Southeast

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    What a great concept - there are doctors who understand more about this illness than we do! - quite a change from our normal experiences with doctors, I’d guess! ;)
     
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  7. Snow Leopard

    Snow Leopard Hibernating

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    Anyone know how these sorts of graphics were generated (the network ones)? They look quite nice!
     
  8. alex3619

    alex3619 Senior Member

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    Klimas revealed a while back that this kind of approach indicated a candidate drug therapy for ME/CFS. Five years and I think eight grant applications later she is still looking for funding.
     
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