Some years ago I was briefly seeing an md who was holistic minded. I'd been taking bioidentical hormones in troche form with estrogen, progesterone, and dhea for years, which helped with my sleep and other things immediately, but I was still having a lot of pain. She added 4 mg of pregnenelone to my hormones and within a few days I felt noticeably better. Over the years in an effort to cut back on estrogen, and to save money, I've tried taking less of the troches. Every time, it seems within a week, I start to experience rampant pain all over my body again. Yesterday I finally googled " pregenelone for pain" and a number of articles came up on it, so I'm curious if others have noticed improvement of pain with pregnenelone. I know I have osteoarthritis throughout my spine, as well as other spinal problems, and some of what I've read indicates it can help with that. Who knows what all the pains are from, but I'd love to hear others experiences. Thanks.