When I drink a cup of coffee the caffeine works nearly right away or atleast in a couple of minutes. This is not true though since caffeine takes longer time to have an effect and I notice the much longer time for it to have an effect when I use caffeine pills (like 20 minutes). Even though I taken a couple of pills in my days it will not have a faster effect when I take the pills now than before. This seems to indicate that this is behavioural conditioning placebo regarding coffe since then I (my body) knows the look, taste and smell of coffee and what it does to my body. I think my body somehow then starts to mimic the effect of caffeine. It does not do that with caffeine pills since its just my knowledge that the caffeine pills work the way it does but no visual, smell and taste cues, its just a small white pill like every other pill. This effect has some studies to back it up, but I wonder if anyone here used this effect to maybe strengthen the effect of a medicine. For example taking a pill with a colorful fluid that taste unusual (like a combo of different spices) and have a special smell?