In the context of Cort's very interesting article about all the NIH ME/CFS grants of 2015 (which go well beyond just the Lipkin/Klimas/Hanson grants), I'm wondering if there's a difference in focus and scale of research in the US and UK and if so, why. In the US, research focusing on autonomic and exercise challenge (and its immune and other effects on PWME) seems common: do we not get this in the UK because of the BPS school's influence or is it going on and I don't know about it? And 'Big Data' - this thing that Ron Davis and the OMI go in for of going in hypothesis-free and using the new techniques involved to look at everything that's happening at a gene expression level (if I've got that right) and comparing PWME and healthies to determine what's going wrong - we seem to see that in the US work but not the UK work. Is this just my ignorance of the field talking or are there differences between the US and the UK here? And if so, why? Discuss. Again, @Simon, @Jonathan Edwards.