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Urea Cycle: It's a real Pisser - Ammonia, Arginine, Ornithine, Citrulline.

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Jorlev, Mar 14, 2013.

  1. Lotus97

    Lotus97 Senior Member

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    So in general, when supporting the Krebs cycle there can be too much of a good thing?
  2. Lotus97

    Lotus97 Senior Member

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    Swanson was having a sale on Yucca extract, but it's standardized for saponins. Since we don't know the active constituent in Yucca, it might not be a good idea to get a standardized extract. Liquid extracts are fine because their full spectrum. I bought it partially because the saponins are supposed to help with joint pain. Hopefully it helps with ammonia, but I'm also taking a capsule of the whole herb just in case.
  3. xjhuez

    xjhuez Senior Member

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    From a study on sheep:
    Binding ammonia is good, obviously, but I'm not sure if the anti-protozoa effect is part of it as well, or even whether it's a good or bad thing.

    This study may have some interesting info, but I'm not about to buy it.

    Same here. Apparently yucca contains all kinds of interesting chemicals, including resveratrol.
  4. Jorlev

    Jorlev

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    I'm MTHFR A1298C HMZ and CBS C699T HTZ so I am concerned about ammonia.
    I haven't tried Yucca pills or extracts but did just buy a root at Whole Foods. How much of the actual root do you think one would have to eat per meal to be equivalent to a pill of extract form of Yucca?
  5. UM MAN

    UM MAN

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    Jorlev, have you blood tested for ammonia?
    I pee lots of sulfate and have CBS Ho and He, but my blood ammonia was well into normal range.
    So ammonia may not be a concern for you....
    Lotus97 likes this.
  6. Jorlev

    Jorlev

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    Haven't blood tested for ammonia yet but will shortly. Was on a lot of supplements and my Dr want me to stop and clear out so he can see results in a natural state.

    Question on Yucca for those who have been on it a long time:
    Obviously, I would want to take it to lower ammonia but I was reading some contradictory articles on the saponins in it.
    One said it acts as surfactant and cleans the stomach lining and villi. Another said it harms the villi and is toxic.
    Also, do surfactants contain sulfur? I'm trying to lower sulfur as well, being CBS C699T HTZ.

    Would appreciate it if anyone with not only book knowledge by personal long term users of Yucca let me know if one should be concerned about Yucca negatives. Thanks.

    Pee. S. Noticed this morning urine was a little foamy after using Yucca for the first time.
  7. Jorlev

    Jorlev

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    Also read it may be just certain Saponins as there are various types. I guess I'm more concerned with Yucca and perhaps Quinoa saponins.
  8. xjhuez

    xjhuez Senior Member

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    I'm afraid I can't answer any of your saponin questions, as I have the same questions.

    I'm not entirely sold on the safety of yucca. That said, I am sold on it's efficacy - it makes me feel noticeably better. For now I'm sticking with it, but will continue to try and learn more. If you come across anything please post it.
  9. Jorlev

    Jorlev

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    How much Yucca do you take and how often? I don't have pills or extract --just bought a root and eat a slice or two with each meal. Tastes a bit like coconut to me. Curious as to what you feel an effective amount would be and if you've had any reaction to eating too much?
  10. xjhuez

    xjhuez Senior Member

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    Cool - I've never seen actual yucca in a store before.

    I have the Solaray 490mg capsules. I take half the contents with a normal meal and with a large protein meal I take the whole capsule.

    I've not had a negative reaction at that dose. Possibly less energy/drive lately, but it's hard to say, and it could be from a dozen different things besides the yucca.
  11. UM MAN

    UM MAN

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    JORLEV, YUCCA schidigera??????
  12. Jorlev

    Jorlev

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    I know Yucca Schidigera is the one to get, but not sure. Got mine at Whole Foods. Perhaps next time I'm there I can see if someone knowledgeable can tell me. I will say that my urine is noticeably less pungent so I think the ammonia is being bound by the yucca.

    Xjhuez mentions a 490mg capsule. I don't know if that's particularly concentrated but if I cut a slice off the Yucca as thick as 3 or 4 quarters, I don't know how many mg that would be but it seems like it's 5 to 8 capsules. It's a root.
    I don't feel like I'm eating that much. I wonder why people some people are taking as little as a half pill.

    That's why I'd really like some real life input from people who've been eating this root for some time. Would love to hear some anecdotal evidence from those with experience with it.
  13. Jorlev

    Jorlev

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    Also, I've notice that after many blood tests each time my BUN level is pretty high. That's a measure of Nitrogen in the urine. As there is nitrogen in ammonia (NH3) I wonder if this high BUN level is connected to high ammonia.
  14. xjhuez

    xjhuez Senior Member

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    Through trial & error I've determined that half dose gives me the same level of effectiveness as a full dose. It's a new/unknown substance so I tend to be cautious.

    My BUN was 20 as of Feb. (normal range is 6-24)
  15. Nikki

    Nikki

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    Hi :),
    I came across this site while researching for a botanical or natural supplement that would reduce ammonia as a result of the urease release by Helicobacter pylori. One of my text books Herbs and Natural Supplements -an evidence based guide by lesley Braun and Marc Cohen supported the use of l-glutamine for protecting the body from high levels of ammonia as it shuttles nitrogen. It is also involved in production of the antioxidant glutathione. As it is not very soluble or stable,absorbtion is another issue. Doses of 14g/day are well tolerated.Contraindicated in Reyes Syndrome and should be used only under professional supervision with chronic renal failure.
    Wayne likes this.
  16. xjhuez

    xjhuez Senior Member

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    Assuming this diagram is right, I'm wondering where and by what mechanism yucca reduces ammonia?

    From what little I've been able to find, yucca may simply bind with NH3 right in the large intestine, thus there's less free to be absorbed by the portal vein. Or, it actually inhibits bacteria from forming it in the first place.

    Attached Files:

    Star-Anise likes this.
  17. dbkita

    dbkita Senior Member

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    It absorbs ammonia in the gut. It will not stop the bacteria from making it.
  18. xjhuez

    xjhuez Senior Member

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    It seems to do both in ruminants.

    http://www.journalofanimalscience.org/content/77/9/2554.short

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201559/

    http://www.journalofanimalscience.org/content/77/E-Suppl/1.9.full.pdf html

    It might work differently in the human digestive tract, obviously.
    Star-Anise likes this.
  19. dbkita

    dbkita Senior Member

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    We aren't ruminants though :)
  20. xjhuez

    xjhuez Senior Member

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    Yup. Neither are pigs or rats. Doesn't seem like you looked at the journal of animal science link.

    I'm not sure why you're being dismissive when the evidence in other animals indicates yucca does more than simply bind ammonia.

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