Hello, If anyone might be interested and has the time and energy to give me a feedback, I drafted a summary of my hypothesis, symptoms, protocol and tests performed so far, which is available here (#8). While preparing this document I realized that beyond the not-that-rare markers for a PWME (immuno-deficiency markers (inverted CD4/CD8 ratio, and absolute NK count well below range), and positive IgG ABs (with no titers) for EBV, CMV, C.Pneumoniae, and VZV)...... I also have some others markers in line with the Dx (very low Creatine Kinase, gliosis spots in two brain MRI, radiculopathies in spine MRI, and had chickenpox in 1993 at 17 y.o.)...... but that I also have some markers suggesting inquiring for co-morbidities or misdiagnosis could be worthwhile: no inflammation shown by C-Reactive Proteine, low creatinine, high homocysteine, high transferrin saturation percentage, low SGOT/SPOT index, low eosinophils leukocytes, very low ESR, but normal low platelets, high LDL colesterol, low insuline, high HbA1c, urine with bacteria, cetones, leukocytes and mucus I am a partial respondent to a protocol based on suggestions by the www.enterovirusfoundation.org but I am dependant on the protocol and I have the feeling that I am not really tackling the cause of this but rather just the symptoms. When I checked these markers, I though that something else could be worth exploring. Thanks for the suggestions and any insights. I take the chance, at this time of the year, for thanking all the members and administrators that make PR a non-ending source of knowledge and health improvement! Best, S.