Hi, i dont know if this is the right place to post this but i was wondering if anyone has any dea what this actually means or what could be causing it. I had my results back from the mitochondrial profile funtion testmany months ago, but am sill struggling to understand it. I think i have got my head round most of it but have 1 unusual result; Krebs citric acid cycle: "This is going borderline slow at 62.5% (normal range >60%). In order to assess the efficiency with which ADP is converted to ATP, an inhibitor is added and then removed to see how quickly ATP is reformed. Having added the inhibitor one expects levels of ATP and magnesium to drop below 0.3 if this does not happen this suggests there is blocking of the active sites. The acceptable percentage is up to 14% and Justines result is 37% (up to 14%). This suggests that there is significant blockage of the active sites (i.e. complexes I,II,III,IV and V on inner mitochondrial membranes). The likeliest reason for this is toxic stress and we could explore further by doing microrespirometry studies which look at oxidative phosphorylation in more detail. "Justine has very unusual results with respect to ADP to ATP conversion efficiency. Although her conversion efficiency is just about normal at 62.5%, she has 37% blocking of active sites this is unusual normally one would expect such blocking of active sites to reduce ADP to ATP efficiency way below the normal figure of 60%. In this case Justine seems to be able to tolerate quite marked blocking of her active sites but still produce a reasonably normal result." Dr. Myhill. any insights into this would be very greatly appreciated.