Chocolove
Tournament of the Phoenix - Rise Again
- Messages
- 548
There is widespread but unrecognized vitamin A deficiency in advanced modern countries, while:
1) an estimated half the population may be genetically unable to convert carotene to vitamin A,
2) the richest dietary sources of true vitamin A (largely found in liver but also found in lesser amounts in full fat milk, butter, and eggs) which are often avoided by many individuals worried about weight or cholesterol, or due to taste aversion.
3) Vitamin supplements contain carotene rather than true vitamin A to avoid toxic overload from the body's storage of this fat soluble vitamin. Check your vitamin supplement label - it usually lists vitamin A but in the fine print it defines this as carotene. However, carotene is not vitamin A.
4) Carotene conversion by the body to vitamin A is an inefficient process at best.
..................................... When dining, the alpha wolf takes the highly prized liver. .......................................
Vitamin A policies are perpetuating Vitamin A deficiency as a consequence of the misguided presumption that carotene automatically converts to Vitamin A, when for many, conversion is not a reality.
Vitamin A deficiency is life threatening on many levels concerning adults as well as children. The modern presumption that Vitamin A cannot be an issue due to widespread carotene consumption, prevents recognition of the current widespread vitamin A deficiency among many, and promotes treatment failure in major disease.
Vitamin A is crucial to survival - true Vitamin A is required by the adrenals to produce hormones such as cortisol; it is also required by the body to prevent and defend against many viruses which may include those causing cancer; it is required to maintain the integrity of mucous membranes, the defenders at our body entry points through which food, disease and bodily fluids transfer; it is further required for vision; however, body reserves are often depleted due to disease and stress.
Common Genetic Variants and Other Host-related Factors Greatly Increase Susceptibility to Vitamin A Deficiency
by Lara Pizzorno, MDiv, MA, LMT
http://www.lmreview.com/articles/vi...ibility-to-vitamin-a-deficiency/#fn-ref-113-3
"In his presentation at the 2nd Hohenheim Nutrition Conference in Stuttgart, Germany, November 2009, Dr. Georg Lietz of England's Newcastle University, the senior investigator in research published April 2009 in the FASEB Journal (and summarized in our June 2009 LMR review, “Vitamin A – Tolerance Extends Longevity”), reported that a high percentage of women in the UK are at risk of vitamin A deficiency. Two common genetic variants greatly lessen the body’s ability to convert beta-carotene into vitamin A."
http://www.lmreview.com/articles/view/vitamin-a-tolerance-extends-longevity/
Search your own genetic data. Genetic SNPs identified as involving carotene conversion or non-conversion, can be found by querying snpedia for carotene:
http://www.snpedia.com/index.php?title=Special:Search&search=carotene&go=Go
"Genetic polymorphisms also affect the vitamin A equivalency of β-carotene. Recently, 2 common genetic polymorphisms of the BCMO1 gene were identified and were associated with a reduction in intestinal conversion of β-carotene to vitamin A of ∼32–69% in UK women . This recent finding may account for much of the observed interindividual variability in estimates of the vitamin A equivalency of β-carotene in human populations."
Leung WC, Hessel S, Meplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15 '-monoxygenase alter beta-carotene metabolism in female volunteers. FASEB Journal 2009, 23(4), 1041-1053. PMID: 1910364 http://www.fasebj.org/content/23/4/1041.abstract?ijkey=e256e5995f7c5c34aab8ed8f3ed9b9d70975b107&keytype2=tf_ipsecsha
Inefficiencies of human carotene conversion to vitamin A:Kohlmeier RH. . “Vitamin A,” in “Fat soluble vitamins and non-nutrients,”. Nutrient Metabolism. Elsevier: London, p. 464-478..
The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion—evidence in humans
October 10, 2012
1,2,3,4 Marjorie J Haskell
The American Journal of Clinical Nutrition
http://ajcn.nutrition.org/content/96/5/1193S.full
10731492
1) an estimated half the population may be genetically unable to convert carotene to vitamin A,
2) the richest dietary sources of true vitamin A (largely found in liver but also found in lesser amounts in full fat milk, butter, and eggs) which are often avoided by many individuals worried about weight or cholesterol, or due to taste aversion.
3) Vitamin supplements contain carotene rather than true vitamin A to avoid toxic overload from the body's storage of this fat soluble vitamin. Check your vitamin supplement label - it usually lists vitamin A but in the fine print it defines this as carotene. However, carotene is not vitamin A.
4) Carotene conversion by the body to vitamin A is an inefficient process at best.
- Normal absorption of carotenoids is minimal: About 70-90% of ingested retinol is absorbed, but even under optimal circumstances, only 3% or less of carotenoids.
..................................... When dining, the alpha wolf takes the highly prized liver. .......................................
Vitamin A policies are perpetuating Vitamin A deficiency as a consequence of the misguided presumption that carotene automatically converts to Vitamin A, when for many, conversion is not a reality.
Vitamin A deficiency is life threatening on many levels concerning adults as well as children. The modern presumption that Vitamin A cannot be an issue due to widespread carotene consumption, prevents recognition of the current widespread vitamin A deficiency among many, and promotes treatment failure in major disease.
Vitamin A is crucial to survival - true Vitamin A is required by the adrenals to produce hormones such as cortisol; it is also required by the body to prevent and defend against many viruses which may include those causing cancer; it is required to maintain the integrity of mucous membranes, the defenders at our body entry points through which food, disease and bodily fluids transfer; it is further required for vision; however, body reserves are often depleted due to disease and stress.
Common Genetic Variants and Other Host-related Factors Greatly Increase Susceptibility to Vitamin A Deficiency
by Lara Pizzorno, MDiv, MA, LMT
http://www.lmreview.com/articles/vi...ibility-to-vitamin-a-deficiency/#fn-ref-113-3
"In his presentation at the 2nd Hohenheim Nutrition Conference in Stuttgart, Germany, November 2009, Dr. Georg Lietz of England's Newcastle University, the senior investigator in research published April 2009 in the FASEB Journal (and summarized in our June 2009 LMR review, “Vitamin A – Tolerance Extends Longevity”), reported that a high percentage of women in the UK are at risk of vitamin A deficiency. Two common genetic variants greatly lessen the body’s ability to convert beta-carotene into vitamin A."
http://www.lmreview.com/articles/view/vitamin-a-tolerance-extends-longevity/
Search your own genetic data. Genetic SNPs identified as involving carotene conversion or non-conversion, can be found by querying snpedia for carotene:
http://www.snpedia.com/index.php?title=Special:Search&search=carotene&go=Go
"Genetic polymorphisms also affect the vitamin A equivalency of β-carotene. Recently, 2 common genetic polymorphisms of the BCMO1 gene were identified and were associated with a reduction in intestinal conversion of β-carotene to vitamin A of ∼32–69% in UK women . This recent finding may account for much of the observed interindividual variability in estimates of the vitamin A equivalency of β-carotene in human populations."
Leung WC, Hessel S, Meplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15 '-monoxygenase alter beta-carotene metabolism in female volunteers. FASEB Journal 2009, 23(4), 1041-1053. PMID: 1910364 http://www.fasebj.org/content/23/4/1041.abstract?ijkey=e256e5995f7c5c34aab8ed8f3ed9b9d70975b107&keytype2=tf_ipsecsha
Inefficiencies of human carotene conversion to vitamin A:Kohlmeier RH. . “Vitamin A,” in “Fat soluble vitamins and non-nutrients,”. Nutrient Metabolism. Elsevier: London, p. 464-478..
The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion—evidence in humans
October 10, 2012
1,2,3,4 Marjorie J Haskell
The American Journal of Clinical Nutrition
http://ajcn.nutrition.org/content/96/5/1193S.full
10731492