I'm not advocating that anyone do this, although I may try it. However, let's say you think you have adrenal fatigue, and one way to find out is if you take a dose of something that contains cortisol, or a few low doses over the course of the day to see if it affects your symptoms in a positive way. Since we are treating the symptoms, not the numbers, if you feel better, this is essentially confirming that you have adrenal related conditions, or other symptoms like hypothyroid that is caused by adrenal dysfunction. In either case, most people have injuries. I recently had knee surgery, and my knee still tends to swell up from time to time after strenuous activity. It would be very easy for me to go to the Ortho and ask him for a Medrol dose pack for my knee. Technically I would be legitimately treating a condition, but at the same I would start at a high dose of cortisol and it would allow me to gage my bodies reaction while also doing a safe taper off of it. Does this sound logical?