Hi All, I just ran across the following "comment" left by Dr. Art Caylor in the comments section of the Wall Street Journal's latest article on CFS entitled, "The Puzzle of Chronic Fatigue", dated March 5, 2011. I thought it was an excellent and concise commentary, in which he posted a link to the United Mitochondrial Disease Foundation at the end. I thought I would post it here, if for no other reason than to introduce you to a doctor who has some very insightful views on CFS and mitochondrial disease. Wayne ........................................ by Dr. Art Caylor - March 5, 2011 - in the Comments Section of the WSJ I am sure that most of you who are interested enough in this article to read the comments are already aware of the information I am going to provide but if not, then you may want to look into it. There is an emerging group of diseases that have many signs and symptoms in common with CFS/ME. Mitochondrial Diseases or diseases caused by mitochondrial dysfunction present with overwhelming fatigue, neurological dysfunction, muscle pathology, autonomic dysfunction, endocrine dysfunction, etc, etc. Sound familiar?? I will attempt to be brief because much better in-depth resources are available at the website I will provide focusing on Mitochondrial Diseases. The manifestations of this group of diseases arise from damage to cellular energy production which leads to cellular dysfunction, which in turn creates tissue dysfunction which leads to organ dysfunction. You get the picture? The organs or structures that require the most energy will obviously be most affected. The neurological system, muscle of all kinds, GI tract, endocrine structures etc, are commonly the hardest hit. But what makes Mitochondrial Diseases so devastating and so difficult to diagnose is the fact that two people, even identical twins, can have the exact same genetic mutation or mitochondrial damage yet exhibit totally different manifestations and symptoms. The implications of this group of diseases and symptoms are just beginning to be recognized, and the impact of mitochondrial dysfunction on diseases that we have known about for many years is being looked at closely. Recognizing Mitochondrial Diseases is not easy even when you are well aware of them and are knowledgeable about their presentations. Unfortunately very few people even know they exist. But an even bigger problem is the lack of awareness among healthcare providers and worse the lack of knowledge even when aware. There is an old axiom in the medical field that goes something like this: “diagnosing a well known disease is difficult enough, but diagnosing one you aren’t even aware of isn’t going to happen”. My whole purpose of this discussion is awareness. If you don’t know about Mitochondrial Diseases read about them. You will be amazed when you see the many similarities with CFS. But more importantly if you are getting nowhere with the evaluation of symptoms that appear to be CFS/ME, consider one of the Mitochondrial Diseases in your list of other possible diseases. If you want more information about Mitochondrial Diseases check out the website for the United Mitochondrial Disease Foundation or UMDF, www.umdf.org. I think you will be glad you did.