1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
AVIVA Semi-Finals: National ME/FM Action Network is competing for $100,000
The National ME/FM Action Network in Canada is competing for $100,000 for biomedical research of ME and FM in the Aviva Community Fund contest. With thanks to all who helped, they made it through the first round of voting into the Semi-Finals.
Discuss the article on the Forums.

Unique cytokine signature in the plasma of patients with fibromyalgia

Discussion in 'Other Health News and Research' started by Ecoclimber, Apr 18, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

    Messages:
    679
    Likes:
    1,259
    Mercer Island Wa
    J Immunol Res. 2014;2014:938576. doi: 10.1155/2014/938576. Epub 2014 Mar 11.
    Unique cytokine signature in the plasma of patients with fibromyalgia.

    Sturgill J1, McGee E2, Menzies V1.
    Author information

    • 1School of Nursing, Virginia Commonwealth University, Richmond, VA 23298, USA ; Institute of Women's Health, Virginia Commonwealth University, Richmond, VA 23298, USA.
    • 2Institute of Women's Health, Virginia Commonwealth University, Richmond, VA 23298, USA ; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT 05401, USA.
    Abstract

    Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. The lack of a clear etiology of FMS has limited the effective diagnosis and treatment of this debilitating condition.

    The objective of this secondary data analysis was to examine plasma cytokine levels in women with FMS using the Bio-Plex Human Cytokine 17-plex Assay. Post hoc analysis of plasma cytokine levels was performed to evaluate patterns that were not specified a priori. Upon examination, patients with FMS exhibited a marked reduction in TH2 cytokines such as IL-4, IL-5, and IL-13.

    The finding of this pattern of altered cytokine milieu not only supports the role of inflammation in FMS but also may lead to more definitive diagnostic tools for clinicians treating FMS. The TH2 suppression provides strong evidence of immune dysregulation in patients with FMS.
     

See more popular forum discussions.

Share This Page