International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
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Unintentional Overmethylation!

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by GreenMachineX, Jan 21, 2018.

  1. GreenMachineX

    GreenMachineX

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    I’ve been taking the only a couple multivitamins (Thorne 2 a day, LEF 2 per day) and I thought all was fine until recently my doctor told me to increase my b’s, so I bought Methyl-Guard Plus, and the nightmare begins.

    I had no idea what was happening and ended up in the ER twice. I eventually figured out what was happening so I stopped all the vitamins (and all addition supplements) and ended up in a histamine overload state, couldn’t breathe at all and right back in the ER. Now I’m stuck between over- and under- and don’t know what to do next. The undermethylation problem dawned on me last night and a gram of vitamin C and some peppermint tea calmed down at least the breathing difficulties and I slept (kind of).

    Today, I took 1g of vitamin C and just 1 cap of Thorne’s Basic Nutrients 3 (not the recommended 6 caps) with breakfast and still had high histamine symptoms that built until a super strong cup of mint tea with another gram of C and right back into overmethylation! I rode it out until it got too bad about an hour ago and took 500mg taurine and 50mg niacin. This calmed it down a little, but I may need another 50my niacin to sleep.

    Other supplements I’ve used the past year that may have masked overmethylation/undermethylation problems:
    Agmatine
    Citrulline
    Maca
    Ashwagandha
    Rhodiola
    ZMA
    Taurine
    Theanine
    Valerian
    Lemon Balm
    Extra Magnesium, C, D, Zinc
    Ubiquinol
    Jarrow Sleep Optimizer (melatonin, valerian, tryptophan, lemon Balm, hops)

    I think that’s it. My memory of the past 3 weeks is a bit shot, but I’m pretty sure this kicked off when I stopped using agmatine at some point, but I can’t remember why I stopped. Does that make sense that it could hold overmethylation off?

    What can I do to get back to baseline? I’m not trying to increase methylation at all, I just want to feel well enough for a while before starting that process. Is there a good multi that addresses enough of the B’s and everything else without going overboard? I only took 166mcg MTF, 75mcg b12, and 1.6mg b6 in that multi single cap today! I don’t know what to do. I struggle with anxiety issues and crazy blood pressure spikes in all this, so I can’t help but wonder, are the states of over- or under- methylation dangerous in the short term? I feel like I might stroke out in the over-!

    I’m prescribed 125mcg Synthroid (just changed back from Nature-Throid which I believe was giving me palpitations)
    25mg losartan
    1.25mg bisoprolol
    120mg testosterone cyp per week

    I also have clonidine .1mg that my doctor wants me to switch to from the bisoprolol, but I’m apprehensive for whatever reason, even though I’m sure it’s better for anxiety.

    Throughout all this, I’m pretty sure at different time, 500mg agmatine turned off an overmethylation “attack”, and another time 500mg sea salt stopped one. Does that make sense?

    Is it possible to just keep taking 1 cap of that multi and just use 50mg extra niacin a couple times a day to get used to it? Hoping to sleep tonight! All input welcome.

    Thanks in advance.
     
  2. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

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    USA
  3. GreenMachineX

    GreenMachineX

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    That’s great! Thanks.
     
  4. GreenMachineX

    GreenMachineX

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    I’ve been increasing my multivitamin intake the past week and have stayed in the mildly undermethylated state mostly, until today. I took an extra 15mg p5p on top of what’s in Thorne’s Basic Nutrients III (dose was 2 caps) and in an hour was very stimulated, riding that line of too much. 2 hours into it, I took 500mg taurine and 1/4 tsp pink salt and in 30 minutes I’m so calm I’m tired, which for the lack of quantity/quality sleep last night, I should be dragging. This is all very interesting but also frustrating because I’d like to be in between the 2 states. Maybe I’ll try a bit less p5p tomorrow and if it becomes too much again, take 1/8th tsp pink salt instead.
     
  5. GreenMachineX

    GreenMachineX

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    Still figuring this out but doing so much better.

    I figured out if I use 300mcg or more of Methyl-B12 I get weird skin sensitivity reactions, like my dry skin is more itchy, my beard is more prickly, etc. If I use 400mcg methylfolate or more, histamine production is ramped up, but this one I’m not as positive with as the mb12.

    I’m using Life Extension’s 2 per Day which has 150mcg mb12 and 200mcg methylfolate, and 37.5 mg b6/p5p which seems to do the trick for me. But, I’m still having insomnia issues. Maybe I’m still getting too much b6? I’ve recently stopped using Jarrow’s Sleep Support which has 300mg tryptophan and 300mcg melatonin plus other relaxing herbs, but I wonder if over the past year I’ve been using both products, I was ramping up methylation during the day (felt great, endless energy, etc) and using that product at night turned off that methylation overdrive without realizing what was going on?

    I’m also going through ketogenic-adaptation which also gives me insomnia so I’m not really sure what’s doing what. But, I do think I read tryptophan can counter overmethylation but I cannot find where I read that.
     

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