The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Unfolded Protein Response and A Possible Treatment for CFS

Discussion in 'General Treatment' started by mariovitali, May 3, 2015.

  1. adreno

    adreno Homo neanderthalensis

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    I was thinking something along those lines. But would the extracts give any meaning?
     
  2. JPV

    JPV ɹǝqɯǝɯ ɹoıuǝs

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    I saw that, which is indeed a cool feature, but I was thinking more along the lines of some sort of dynamic database that can be used for crowdsourcing information by rating the effectiveness of various treatments. I know that there are a few online health databases that take this approach but it might be nice to have one just for members of this forum and our specific experiments. I'm sure that something exists out there already that would work.
     
  3. JPV

    JPV ɹǝqɯǝɯ ɹoıuǝs

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    That looks great for research but I was thinking more along the lines of something where people could rate treatments and indicate side effects in a dynamic spreadsheet sort of layout.

    This might be too simplistic, but I was thinking something like this...

    CureTogether
     
    Last edited: May 13, 2015
  4. mariovitali

    mariovitali Senior Member

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    Yes that is great, there are actually so many Techniques out there which haven't been put to use as much as they should. We can find common characteristics/combinations of supplements that seem to work better, sequences of events, you name it.


    Anyway, if any admin is reading these messages then i will be happy to help out.
     
  5. mariovitali

    mariovitali Senior Member

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    Basically you can extract a ton of knowledge out of it which of course would be just hypotheses. Out of the top of my head we could see:

    -Most common symptoms
    -Which symptoms tend to occur together
    -Which events happen after a supplement intake
    -Which combinations of supplements shows better results (=lower frequency of Symptoms)
     
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  6. adreno

    adreno Homo neanderthalensis

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    That sounds interesting. So that is essentially machine learning algorithms.

    I suggest we make a new thread about it, and get more people and ideas on board.
     
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  7. JPV

    JPV ɹǝqɯǝɯ ɹoıuǝs

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    We need to do something. The data on the site is getting somewhat unmanageable.
     
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  8. ZudZud

    ZudZud

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    It can be done with a large database using associations, but the real problem will be people randomly upvoting/downvoting substances, symptoms and general spam. It needs full time watchdogs and the end result might not reveal so much. It's as much of a technical challenge as it is a human issue. However, it could be awesome.

    See imdb ratings, iherb reviews, etc. for general problems with such systems.
     
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  9. xks201

    xks201 Senior Member

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    I am presently learning computer programming and I believe this would make a good project for me. There already Is a website covering all medical conditions showing drugs reviews per conditions but this is a bit more specific. I don't know if I'd call it s machine learning but it is more specific.
     
  10. mariovitali

    mariovitali Senior Member

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    Dear All,

    After doing more research about my condition i realized that i have to check my kidney function and whether i am in the route towards Chronic Kidney Disease (CKD).

    So i visited a Pathologist whom i never seen and went there prepared with several PubMed printouts and explained to him what i think is going on (Methylation Problems, Insufficient BH4 and Ultimately UPR as part of the Mechanism). He was very open and said that whatever i said made perfect sense to him but OTOH we cannot prove anything.

    I have found 3 times elevated Creatinine and Urea but never had eGFR so i will be doing these next week. I am Keeping my fingers crossed...



    Please make sure that you do not have BH4, GCH1 Mutations because this will impair dopamine, serotonin, epinephrine, your Nitric Oxide production and ultimately your kidneys (among other things).

    Please also visit this thread
     
  11. nandixon

    nandixon Senior Member

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  12. mariovitali

    mariovitali Senior Member

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    @nandixon

    Yes that makes sense but i would like to take all things under consideration (which as you pointed out correctly, should be addressed whenever i talk about impaired BH4 Production). I could definitely see some issues with Dopamine, Epinephrine and Nitric Oxide production. My NO was very low actually. So perhaps my Methylation problems + GCH1 impairs Dopamine/Adrenaline production.
     
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  13. Gondwanaland

    Gondwanaland Senior Member

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    @mariovitali interesting... When I open my Promethease report my top detrimental SNPs point to urinary tract problems (kidney disease, bladder cancer). I hope I can decipher this thread and the one you linked soon. I think am having very low dopamine and adrenaline as well.
     
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  14. mariovitali

    mariovitali Senior Member

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    FYI @nandixon

    More evidence on how Resveratrol could help achieve better BH4 levels :


    and (this has been posted before)




    I believe that induction of BH4 levels was very important for my recovery.
     
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  15. nandixon

    nandixon Senior Member

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    @mariovitali

    I tried resveratrol 2 or 3 years ago, and didn't notice much effect. Perhaps slightly positive, but not worth the high cost. I used the best (I think) product available at the time, which was Biotivia Transmax Trans-Resveratrol (500 mg).

    The problem with resveratrol is that it does a great many things - perhaps too many things, many or most of which are only achievable in vitro. So it may be difficult to tell what effect it's really having if a person experiences a benefit from taking it.
     
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  16. mariovitali

    mariovitali Senior Member

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    Resveratrol has definitely helped me. I know this because at that time i was not getting anything else and i felt an immediate boost (but which on its own wasn't enough).

    Needless to say that this condition we are having needs personalized therapy with many different parameters that have to be accounted for.
     
  17. adreno

    adreno Homo neanderthalensis

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    I did find it stimulating. Unfortunately, it made me quite aggressive, like dopamine rage. It also seems to be a nitric oxide killer.
     
    Last edited: May 16, 2015
  18. Sidereal

    Sidereal Senior Member

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    I can't tolerate fexofenadine at all.
     
  19. adreno

    adreno Homo neanderthalensis

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    What happens?
     
  20. Sidereal

    Sidereal Senior Member

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    Agitation.
     

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