Greenshots, I am so glad to read this, because it makes me feel better about feeling poorly. (Kind of like when I was awake all night out of excitement and relief after I found out I was compound heterozygous for MTHFR!) People (not even family) don't understand why my body acts like it does, and why I have no energy. It's not something I am choosing, but they can't allow for anything beyond what their own experience is with their own bodies, and what they see externally of others. I've basically spent more than I can afford already on the tests that I've had -- I might stretch to the cortisol saliva test or the ACTH blood test, because one of the two might give me some important info about my adrenal situation -- so, for now at least, I won't be doing any toxin testing or the other really interesting-sounding tests that are out there (like neurotransmitters, ION, Nutreval, etc.) I have to admit that I am unprepared for what detoxing might entail - I will need to start with low doses, and continue reading up on everyone's experiences with methylation. Experiencing a surge of anything would be a novelty for my tortoise-like constitution. Seriously, though, I know it's a big deal. I bought some SAM-e last year but was afraid to use it (because of various warnings), so it's still unopened. I think I read last week that for one of my mutations that SAM-e was not a good idea. It's hard to balance all these things out when not working with a medical practitioner who has loads of knowlege and experience about how all the overclocking and underclocking of the patient's unique chemistry will work in concert with the supplements. I was disappointed to find that the heartfixer site says it does not know much about ACAT and can't recommend what to do about it. This (genetic and methylation stuff) is like a parallel world I've fallen into (without having anyone in my day-to-day life I can talk about it with) over the last few months, and it's nice to find some company here with people like yourself who know all the terminology and the reality of these complex and invisible physical processes that have so much impact on one's life.