What I meant by "Would it be too roundabout to first consult with some kind of integrative doctor who would have the ability to bear in mind all my other test results (even, if possible, the genetic mutations - though that is probably too much to ask)?" was the sort of MDs who go through Dr. Weil's Integrative Medicine program at the University of Arizona medical school (http://integrativemedicine.arizona.edu/about/index.html) -- or the sort of thorough doctor that Dr. Mirza the thyroid specialist who wrote those comments in the BMJ seems to be (spending a long time with the patient, getting the complete picture). I think osteopaths can order all tests and prescribe all medicine and so forth in the US - they are considered full physicians here, as far as I know. In other countries, the profession is a bit different (Wikipedia tells me, anyway!) I grew up in the US, but I lived in Europe for many years, so I am not familiar with the intricacies of the current American healthcare system. It looks as if Americans directly go to gynecologists, podiatrists, opthalmologists, etc. without going through a GP first (at least, if they aren't locked into an HMO or PPO set-up with their health insurance plan), but I can well see that going to an endocrinologist or oncologist directly might be incorrect and too bold. Not that I wouldn't be one to try!