I guess this is "get to know the disease" day for me, I am asking a few questions like this lately... I generally get lactic acid buildup and sometimes pain for days if I overdo it physically, but I don't think I've had a severe bedbound type crash. It's more like "I need a recovery day or 2." My exercise tolerance is crap, but still, I can move around enough to get basic stuff done... On the other hand, if I overdo it mentally or emotionally, I have a week or more where my brain just goes out of control with terrible anxiety bordering on psychosis for no reason. It lasts hours at a time 2 - 3 times a day. Like I will try to tear my own head off, weep, scream crazy things at everybody around me, try to figure out how to kill myself, that sort of pleasant thing. Then I experience something that feels a lot like hypoxia (I used to be a swimmer so I know what that feels like) and get kind of giddy and relaxed, though I am pretty sure brain cells are dying off. During these periods I often can almost forget how to talk. I also tend to run hot (99-100 vs 97 usual) during this. Sometimes cold water dumped on the head can snap me out of it temporarily. I have learned that panic attacks are related to lactic acid buildup in the brain, maybe it's related? I haven't had such a problem since I started treating with sodium and potassium bicarbonate twice a day. But who knows if that will last, it's only been a couple weeks. Does this click with anybody? Or are most people's crashes straight up crashes?