I am looking to calm down microglial hyper activation. I tried using LDN at a dose of .25 and some times even smaller than that. It didn't help and maybe made things worse. I believe its mostly due to its effects on the opiods, which can be quite high in people with neuroinflammation. Now I am wondering if its possible to try even the smallest of small doses to correct this issue, even a fraction of .25. Has anyone ever attempted this?