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Ultra Low Dose Naltrexone plus opioid for better pain relief

Discussion in 'Pain and Inflammation' started by PatJ, Jun 20, 2017.

  1. PatJ

    PatJ far and free I gaze

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    This article explains how Ultra Low Dose Naltrexone (ULDN) can be used with opioids to improve the pain relief effect provided by the opioids and avoid the increase in pain that is usually associated with long term use.

    "Ultra-low-dose naltrexone seems to help block the activation of glial cells caused by long term opioid use, and prevent the amplification of pain that can be induced by long-term opiate use. At very low doses it can do this without blocking the pain-relieving actions of the opiates. The key is finding the dosage sweet spot where LDN is able to calm the glial cells, but not knock the opiates off their receptors. That sweet spot seems to be around 0.5–1mg, called ultra-low-dose naltrexone (usual low-dose naltrexone is 3–4.5mg)."

    For those who deal with pain this might be a useful treatment to look into.
     
    Last edited: Jun 21, 2017
  2. Sushi

    Sushi Senior Member Albuquerque

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    Perhaps your could write that out in the title of your post as many may just pass over ULDN, not knowing what it is.
     
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  3. TrixieStix

    TrixieStix Senior Member

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    I take opiates and my ME/CFS specialist had me try ULDN (ppl on opiates can only do ULDN) but unfortunately I had a bad reaction to it just hours after my very first dose. Was such a bummer.
     
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  4. PatJ

    PatJ far and free I gaze

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    It's possible to use regular Low Dose Naltrexone even when taking opiates. LDNScience.org has this to say about it:
     
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  5. TrixieStix

    TrixieStix Senior Member

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    I guess I more meant ppl who have to take them daily round the clock (either short acting taken multiple times daily or long acting). It also depends on how large of a doseage a person is taking.
     
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  6. panckage

    panckage Senior Member

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    Another alternative is the supplement kratom. Gives similiar benefits as opioids but with less issues with withdrawal/tolerance
     
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