Jen Brea launches mass-advocacy platform — #MEAction goes live!
Jen Brea is a phenomenon. After working as a freelance writer in China and Africa, she enrolled for a PhD at Harvard in political science but, four years ago, got sick. She had a fever that lasted ten days.
Discuss the article on the Forums.

UK, The Times, 23 Apr: 'Biological breakthrough offers fresh hope to ME sufferers

Discussion in 'General ME/CFS News' started by filfla4, Apr 23, 2013.

  1. Sean

    Sean Senior Member

    Messages:
    1,763
    Likes:
    4,852
    I think that is highly likely to be the case for at least a substantial portion of 'psych' symptoms and diagnoses, such as depression, anxiety, phobia, etc.

    One of the reasons the psychs have tried so hard to portray us ME patients as primarily psych cases is because if it is not true, they are in deep shit about a whole lot of stuff beyond just us.
     
    justinreilly, Allyson and ukxmrv like this.
  2. clive powney

    clive powney Senior Member

    Messages:
    177
    Likes:
    113
    coventry
    The Newcastle team (Julia Newton) are now recruiting for a project titled 'Understanding the pathogenisis of autonomic dysfunction in CFS and its relationship with cognitive impairment '
    http://gtr.rcuk.ac.uk/project/C450A957-9885-4E43-AD9D-1E5364BC07AF
     
    Little Bluestem and Marco like this.
  3. Marco

    Marco Old blackguard

    Messages:
    1,788
    Likes:
    1,657
    Near Cognac, France
    Thanks Clive

    That's what I like to see!
     
  4. baccarat

    baccarat Senior Member

    Messages:
    188
    Likes:
    81
    it's a shame available funds allow such restriction in studies scope and sample sizes.
    when i think it would only take a fraction of the annual salary bill of your average premier league football team to have a good study with a properly sized sample etc to finally ridicule any idea that cfs is not a biological illness, my bp tends to rise...
     
  5. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    5,832
    Likes:
    7,656
    Cornwall, UK
    I wouldn't want them anywhere near mine!
     
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    5,832
    Likes:
    7,656
    Cornwall, UK
    One thing I have always struggled with in chemistry is how to control the processes that can go in both directions, such the oxygenation of lactic acid to lactate and the reduction of lactate to lactic acid. I know that it involves the addition and removal of hydrogen (H+) ions (protons) but can't figure out how to safely improve the balance physiologically, especially in ATP production.

    These links provide useful info but I just can't retain it or remember it!

    http://fitsweb.uchc.edu/student/selectives/TimurGraham/Lactic_Acidosis.html

    http://ceaccp.oxfordjournals.org/content/6/3/128.ful

    I do agree about preventing it from building up, but how can we do that other than being slightly more active than a corpse? I am trying to address build-up from all the theoretically (i.e. in the absence of real-life essential activity) effective ways - reducing carb consumption, trying to minimise stress and avoiding over-exertion. But even a visit to the doctor yesterday (unrelated to ME) has worn me out.

    All-too-familiar story, I am sure.
     
  7. alex3619

    alex3619 Senior Member

    Messages:
    9,143
    Likes:
    17,755
    Logan, Queensland, Australia
    We probably wont be able to control the acidity until we understand the underlying process. In the meantime I have no doubt we will try lots of things, and maybe we will get lucky and find something that works. Julia Newton's samples can be used to test things: as a test platform it will be invaluable.

    One thing that is being missed here is that low pH, and indeed high pH, will modify enzymatic reactions ... a lot of them. Exactly what is being modified? This could get very interesting.
     
    Allyson and Enid like this.
  8. SilverbladeTE

    SilverbladeTE Senior Member

    Messages:
    2,329
    Likes:
    2,068
    Somewhere near Glasgow, Scotland
    I'm WELL ready :p

    [​IMG]

    001-1118091708-braveheart-Kilt-Ass.jpg
     
  9. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    5,832
    Likes:
    7,656
    Cornwall, UK
    Can you name some of these?
     
  10. Persimmon

    Persimmon Senior Member

    Messages:
    122
    Likes:
    158
    One great thing about the article is that it exclusively uses the term ME - no mention at all of CFS!
     
    Allyson likes this.
  11. Bob

    Bob

    Messages:
    10,441
    Likes:
    19,358
    South of England
    Allyson likes this.
  12. Esther12

    Esther12 Senior Member

    Messages:
    5,858
    Likes:
    7,807
    I don't understand a lot of the specifics with regards to epigenetics, or the way cells were cultured here - but I'd still hope that the control samples came from deconditioned/sedentary non-CFSers. There are so many mechanisms within the human body that we do not understand, that it we are trying to separate causal and secondary changes in CFS it always seems sensible to try to use sedentary controls for these sorts of studies.
     
    Allyson and Sasha like this.
  13. Simon

    Simon

    Messages:
    1,920
    Likes:
    7,153
    Monmouth, UK
    This group has used sedentary controls in previous studies but I'm not sure there's much point speculating further until it's published.
     
    Allyson likes this.
  14. Gijs

    Gijs Senior Member

    Messages:
    269
    Likes:
    337
    Yes, they used sedentary controls in this study. They take cells from muscle biopsies in patients with CFS/ME and grow those muscle cells in the laboratory. So, these cells aren’t being influenced by anything else within the human. It is not because CFS-patients aren’t exercising and become deconditioned because these laboratory experiments with these cells can't be influenced by deconditioning and the MRI studies show that the severity of the acid accumulation is directly related to the degree of abnormality with the autonomic nervous system
     
    Allyson and ukxmrv like this.
  15. adreno

    adreno Learned helplessness

    Messages:
    3,532
    Likes:
    4,023
    Europe
    Bicarbonate, citrulline, carnosine.
     
  16. Mark

    Mark Acting CEO

    Messages:
    4,683
    Likes:
    2,364
    Sofa, UK
    Yes, the Times article does state that the controls were sedentary, which is of course a very important issue in this particular study. I think this may well be a very significant milestone, politically at least. Is this the first ever government/MRC-funded study to demonstrate biological abnormalities in ME/CFS? Excess lactic acid in ME/CFS patients is not really news, I think, but demonstrating it in vitro is new to me.

    It has really got me thinking about where it fits as a link in the chain of symptoms, because it seems to me that it may fit in quite a clear way. Excess lactic acid production will obviously cause much greater pain and fatigue, but I'm interested in how this might fit in with sleep and PEM. PEM symptoms typically come 24-48 hours after exertion - or to put it another way, after 1-2 night's sleep with masses of excess lactic acid. Anybody have any clues on the biology of how excess lactic acid might be expected to produce the other known PEM symptoms, and the inflammatory markers of PEM found by the likes of the Lights' studies? And then, in the other direction, any thoughts on what kind of cell malfunction (eg mitochondria issues) might cause excess lactic acid production?
     
    Allyson likes this.
  17. PhoenixDown

    PhoenixDown Senior Member

    Messages:
    265
    Likes:
    243
    UK
    Promising stuff, where did they get that 600,000 figure from though?
     
    Allyson likes this.
  18. lansbergen

    lansbergen Senior Member

    Messages:
    1,607
    Likes:
    1,070
    Do they mean latic acid? I didnot see it in the press release.

    I am thinking of superoxide.
     
  19. beaker

    beaker ME/cfs 1986

    Messages:
    616
    Likes:
    1,271
    USA
    Does anyone know if the proceedings of the conference where this was presented will be published in a scientific journal ? Most peer review journals don't want to publish something that has been in the media, unless it is proceedings from a conference.
    My M.D. is a straight line academic. He will want a published paper to take it seriously. Unfortunately, that is true for most of academia in the US.

    ETA: results confirm what my muscles have felt for a long long time. I ( and I know many of you ) have even described it as lactic acid burns. I'm glad they finally came up with a nice way of showing it !
     
  20. Tristen

    Tristen Senior Member

    Messages:
    624
    Likes:
    447
    Northern Ca. USA


    Me too. Sometimes, even just stretching sets me off. Also agree on it just seems a better way of demonstrating what we already knew. The study should at least get more attention in the research community.
     

See more popular forum discussions.

Share This Page