Hello and thank you to all the people who gave me some advice a few weeks back. After considering what everyone was saying, we decided to try Rich's revised simplified protocol on my husband, and see what happened. Our biggest fear was that nothing would happen, but quite the reverse, we got quite a number of the side effects of die-off and detox, as listed on Dr. Myhill's site. He has been feeling muzzy and dozy, with the waxing and waning fatigue (taking mid-day rests and going off to sleep - healing naps!), he has been a bit irritable if I'm honest, some strong emotions, runny nose, sore throat, effects on bowel movements and unusual colour of stools. On the positive side, he did feel at one point that his typing had sped up when he worked, and he has sometimes slept through the night, which is rare. So something is definitely happening. The only problem is, that overall, he is not feeling too great about it. He has cut the medication down to the lowest possible doses of everything, and intends to build up when his body is more used to the vitamins, and last night, decided that he would take a 'day off' from them, and so took nothing - was this a bad decision? So I suppose my question is, how long has it taken for other people to adapt to having the vitamins in their system? How long does the 'die off' phase last? He is quite happy to continue with the protocol if eventually his system will pick up, but just needs some words of encouragement from anyone who has gone through this before and come out the other side. Obviously we know that what happens to one person cannot be guaranteed to happen to another, but it is a question of how long do we continue with this experiment if it is mainly generating unpleasant side effects? Many thanks in advance for any replies.