Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Tryptophan neuroinflammation article

Discussion in 'General ME/CFS News' started by SwanRonson, Jul 1, 2015.

  1. SwanRonson

    SwanRonson Senior Member

    Messages:
    289
    Likes:
    201
    Alabama
    http://www.cortjohnson.org/blog/201...-kynurenine-pathway-in-fibromalgia-and-mecfs/

    After reading the above post by Cort, I'm wondering if supplemental tryptophan is a bad idea. I've been supplementing it in small amounts lately (500mg once daily) just seeing if it helps with gut motility. If it's being converted to neurotoxins then it seems best to supplement melatonin and seratonin(via 5htp) directly. Any thoughts?
     
  2. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,425
    Likes:
    1,027
    Wouldn't one notice an increase in negative symptoms if the tryptophan was taking the wrong pathway?
    I have been using 500-1000mg/day of L-tryptophan for the past 6 months without noticeable side effects, so I'd presume it's not causing any harm.

    I don't have experience with melatonin supplements, and 5HTP doesn't do good things for me, so I can't help much on that.

    cheers
     
  3. liverock

    liverock Senior Member

    Messages:
    692
    Likes:
    1,194
    UK
    I have also found taking 1,000mg of tryptophan just before going to bed to improve sleep and mood the following day. Its probably only a small subset of PWME who are having problems
    with tryptophan.
     
  4. john66

    john66 Senior Member

    Messages:
    156
    Likes:
    140
    Ray Peat writes about tryptophan and it's effects on the body. He also claims fish oils and put a ' s are bad. Lots of youtube info as well.
     
    SwanRonson likes this.
  5. SwanRonson

    SwanRonson Senior Member

    Messages:
    289
    Likes:
    201
    Alabama
    I've honestly never known what to do with Ray Peat. He seems to know his stuff. But it's so contrarian at certain points combined with being so voluminous that it's almost impossible (for me) to critique.
     
  6. Fandol

    Fandol

    Messages:
    1
    Likes:
    2
    I think the tryptophan-neuroinflammation/fibromyalgia connection has an awfully strong familiarity with the tryptophan disaster of 1989 resulting in eosinophilia myalgia syndrome, and interestingly, even pure tryptophan supplements have been tied to this disorder and other problems - I'm new here so I can't post a link but google to read a scholarly article on that "L Tryptophan: The Truth About The FDA Tryptophan Recall Of 1989"
     
    Gondwanaland and SwanRonson like this.
  7. SwanRonson

    SwanRonson Senior Member

    Messages:
    289
    Likes:
    201
    Alabama
    In following up on what Ray peat said yesterday he mentioned the same thing about the recall. What he had said makes a lot of sense that isolating amino acids can have a radical effect on the brain. Thanks for the link.
     
  8. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,954
    Likes:
    12,761
    Cornwall, UK
    Just to say that since finding out about the kynurenine issue, and having low mood, I started supplementing 5-HTP and it improved my mood (in a few weeks) with no apparent ill effects. I'm also fine with melatonin.
     
    natasa778 likes this.
  9. SwanRonson

    SwanRonson Senior Member

    Messages:
    289
    Likes:
    201
    Alabama
    Are you supplementing 5-htp as a way to get serotonin directly without using tryptophan?
     
  10. SwanRonson

    SwanRonson Senior Member

    Messages:
    289
    Likes:
    201
    Alabama
    i created a thread here. for this discussion so it doesn't clog up the news forum.
     
  11. john66

    john66 Senior Member

    Messages:
    156
    Likes:
    140
    I tthink Rey is quite a few pay grades headof me. scieohnce and medicine to separate fieldsscience
     
  12. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,455
    I've found 5htp to be Very dose-sensitive, with massive difference in effects between different dosages, as in bottle dosage instructions led to bad mood swings, halving the dose = lovely calming effect with no negatives.
     
  13. liverock

    liverock Senior Member

    Messages:
    692
    Likes:
    1,194
    UK
    It might take time for side effects to emerge. Its best not to take it for more than a month or so with vitamin B6 which can help getting rid of metabolites. I only take it for short periods when having sleep problems.

    Tryptophan can cause some serious side effects if taken for a long time..

    http://www.supplements-and-health.com/tryptophan-side-effects.html
     
  14. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,954
    Likes:
    12,761
    Cornwall, UK
    Take care with B6 - some of us can't tolerate it.
     

See more popular forum discussions.

Share This Page